Avicenna Journal of Phytomedicine

Volume & Issue: Articles in Press

Articles in Press: ALL Accepted Manuscript Corrected Proof

Review Article

Antioxidant, anti-inflammatory and cytoprotective effects of crocin, a bioactive constituent of saffron, in Alzheimer’s and Parkinson’s diseases with a focus on molecular mechanisms: A systematic review

Articles in Press, Accepted Manuscript, Available Online from 06 May 2025

Zahra Tayarani-Najaran; Elham Hadipour; Shirin Ramazani; Leyli Taghizadeh; Elham Ramazani

Impact of flavonoid-rich herbal medicines on idiopathic heavy menstrual bleeding: A systematic review and meta-analysis of randomized controlled trials

Articles in Press, Accepted Manuscript, Available Online from 13 May 2025

Marzieh Qaraaty; Ayesheh Enayati; maedeh rezghi; Abdolhalim Rajabi; Mojgan Tansaz; Masoud Mohammadi; Amirhossein Sahebkar

Original Research Article

Nordihydroguaiaretic acid attenuates TNFα-dependent intercellular adhesion molecule-1 expression in cultured human umbilical vein endothelial cells via targeting TNFα-PI3K-NF-κB-ICAM1 pathway

Articles in Press, Accepted Manuscript, Available Online from 21 June 2025

Tapan Kumar Mukherjee; Parth Malik; Raj Singh; Vishal Patel; Raman Kumar

Wortmannin exhibits anticancer activity in oral cancer cell line by targeting PI3K, AKT and mTOR pathway

Articles in Press, Accepted Manuscript, Available Online from 21 June 2025

GAURI M. KUMBHAR; Poonam Suryawanshi; VAIBHAV SUNIL LADKE

Rice bran oil ameliorates the symptoms of benign prostatic hyperplasia in male Wistar rats

Articles in Press, Accepted Manuscript, Available Online from 25 June 2025

Md Shaki Mostaid; Md Ashik Miah; Mafuja Akter Sathi; Md Golam Hasib; Muktadiur Rahman; Nabila Mahmud; Manik Shill; Hasan Mahmud Reza; Murad Hossain; Muhammed Mahfuzur Rahman

Short communication

Almond for mild to moderate Alzheimer’s disease: A randomized clinical trial

Articles in Press, Accepted Manuscript, Available Online from 29 June 2025

Mohsen Mohajeri; Fataneh Hashem-Dabaghian; Shima Raeesi; Somaye Mahroozade

Original Research Article

Evaluation of the monotherapy effect of crocin on mild-to-moderate diabetic retinopathy: A randomized clinical trial

Articles in Press, Accepted Manuscript, Available Online from 01 July 2025

Sayed Ahmad Mohajeri

Evaluation of nano-curcumin oral formulation efficacy in prevention of chemotherapy-induced adverse reactions in metastatic colorectal cancer patients

Articles in Press, Accepted Manuscript, Available Online from 02 July 2025

Mahdi Jannati Yazadan Abad; Abolghasem Allahyari; Mostafa Kamandi; Omid Arasteh; Mehdi Varmaghani; Hedyieh Karbasforooshan; Mahmoud Reza Jaafari; Hamidreza Kheradmand; Abolfazl Eftekhari; Sepideh Elyasi

Suppressive effect of lemon (Citrus limon L. Burm. f.) extract toward pro-tumor immune response in DMBA-induced carcinogenesis mouse

Articles in Press, Accepted Manuscript, Available Online from 12 July 2025

Wira Eka Putra; Chalissa Nuruzzulfa; Dea Esaayu Mahabella; Ramdhani Faradilla Intania Nuraıda; Arief Hıdayatullah; Muhaimin Rifa’i

Review Article

Possible therapeutic effects of Plantago major in women with high menstrual bleeding: A systematic review of randomized clinical trials

Articles in Press, Accepted Manuscript, Available Online from 15 July 2025

Mohammad Reza Khazdair; Majid Kianmehr

Original Research Article

The modulatory role of 6-gingerol-rich portion of ginger on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed male Wistar rats

Articles in Press, Accepted Manuscript, Available Online from 16 July 2025

Maryam Tayo Ayinla; Abraham Olufemi Asuku

Review Article

Kombucha tea in cancer care: A review of its anti-cancer potential and role in integrative oncology

Articles in Press, Accepted Manuscript, Available Online from 19 July 2025

Maryam Sarshar; Leyla Azmayesh; Faeze Khoshhal; Samira Kabudani; Meysam Beyrami; Majid Rajabian; Maryam Moradi-Binabaj; fereshteh asgharzadeh

Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis

Articles in Press, Accepted Manuscript, Available Online from 24 July 2025

Fatemeh ghaemi; maryam emadzadeh; wael almahmeed; Tannaz Jamialahmadi; Sercan Karav; Amir Hossein Sahebkar

Original Research Article

Phytochemical profiling and anti-obesity potential of the methanol extract of Carica papaya ripe fruit peel

Articles in Press, Accepted Manuscript, Available Online from 05 August 2025

Rimsha Ahsan; Kanwal Ashiq; Shafiq Ali Shah; Muhammad Zaeem Ahsan; Shafiullah Shafiullah; Maryam Ashraf; Ishafaq Bukhari

Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats

Articles in Press, Accepted Manuscript, Available Online from 11 August 2025

Mohaddeseh Sadat Alavi; azar Hosseini; Fereshte Torabi; Mitra Rayati banadkooki; Zahra Taghadosi; Mohammad Taher Boroushaki

Review Article

The efficacy of Hypericum perforatum L. for the treatment of premenstrual syndrome: A systematic review and meta-analysis

Articles in Press, Accepted Manuscript, Available Online from 19 August 2025

leila bozorgian; saeed ghanbari; Javad Mottaghipisheh; Maryam Zahedian; Parvin Abedi; Solmaz mohammadi

Original Research Article

A preliminary pilot study of the effect of oatmeal and oxygen–ozone (O2-O3) administrations on NRF2 pathway-related antioxidants after intense exercise

Articles in Press, Accepted Manuscript, Available Online from 26 August 2025

Sadegh Abbasian; Zohreh Mortezae; Mahsa Kargar Moghadam; Hamid Moghavemi; Hamed Ameri Afzadi; Mahboobeh Ghasemzadeh Rahbardar; Mohammad Ali Sardar

The effect of curcumin and piperine co-supplementation on glycemic indices in prediabetes: A triple-blind randomized controlled trial

Articles in Press, Accepted Manuscript, Available Online from 26 August 2025

Hossein Ghazaee; Amirhossein Sahebkar; Zahra Mazloum Khorasani; Maryam Emadzadeh

Short communication

Crocin mitigates colistin-induced toxicity in HEK-293 cells through anti-oxidant and antiapoptotic mechanisms

Articles in Press, Accepted Manuscript, Available Online from 26 August 2025

Bibi Marjan Razavi; Majid Keshavarzi; Sina Dorostkar; Hossein Hosseinzadeh; Mahboubeh Ghasemzadeh Rahbardar

Original Research Article

A clinical study on Clitoria ternatea tea therapy to manage diabetic distress in people with type 2 diabetes

Articles in Press, Accepted Manuscript, Available Online from 27 August 2025

Vadivel MANI; Ramya Badrachalam; Brindha S; Muninathan N; Sangeeta Chandrashekar; Nisha K; Swapna Dileep Garikimukkala; Sadhana Undru

Comparison of Hibiscus sabdariffa L. extract and hydrochlorothiazide as adjuncts to Valsartan in managing hypertension in type 2 diabetic nephropathy: A randomized clinical trial

Articles in Press, Accepted Manuscript, Available Online from 27 August 2025

Hassan Mirzaei; Ayesheh Enayati; Maryam Kiani; Somayeh Ghorbani; Gokhan Zengin; Saeid Amirkhanlou

Rhizophora apiculata extracts improved memory function through inhibition of acetylcholinesterase and oxidative stress in scopolamine-induced memory deficits in rats

Articles in Press, Accepted Manuscript, Available Online from 30 August 2025

Annie Mande; Malothu Narender; Chakravarthi Guntupalli; Kakarla Ramakrishna; Sathish Kumar Konidala

Vitex agnus-castus extract improved the endocrine profile and important gene expression in rat ovaries with polycystic ovary syndrome

Articles in Press, Accepted Manuscript, Available Online from 06 September 2025

Mahtab Abbaszadeh; Gholamali Jelodar; Saeed Hossainzadeh; Azam Salmani

Dexamethasone-induced hepatic biochemical and pathological damages are attenuated by Cynodon dactylon extract containing hexadecanoic acid via reduction of glucose uptake: In vitro and in vivo studies

Articles in Press, Accepted Manuscript, Available Online from 06 September 2025

Sadaf Mottaghian; Ayshin Khalilarya; Hassan Malekinejad

Short communication

Oren-gedoku-to suppresses hypothalamic adenosine 5′-monophosphate-activated protein kinase activity and olanzapine-induced hyperglycemia

Articles in Press, Accepted Manuscript, Available Online from 06 September 2025

Yuna Kusakabe; Yasuyoshi Ishiwata; Masashi Nagata

Original Research Article

Lycopene suppresses α-cypermethrin nephrotoxicity: An insight into its modulatory effect on oxidative stress-mediated pro-inflammation, DNA damage and caspase apoptosis in Wistar rats

Articles in Press, Accepted Manuscript, Available Online from 09 September 2025

Hany Elsawy; nourah almulhim; manal alfwuaires; azza أا sedky

Short communication

Therapeutic effects of Zataria multiflora Boiss. extract-loaded chitosan nanoparticles against asthma in rats

Articles in Press, Accepted Manuscript, Available Online from 09 September 2025

najmeh parvaz; Mahboubeh Mirhosseini; Saeideh Saadat; fatemeh Amin; Leila Etemad

Original Research Article

Hepatoprotective effects of cinnamaldehyde against high-fat diet-induced liver damage

Articles in Press, Accepted Manuscript, Available Online from 14 September 2025

Reyhane Farmani; Mehran Hosseini; ُSamaneh Nakhaee; Zomorrod Ataie; Khadijeh Farrokhfall

Evaluation of the preventive effect of intravenous trans-sodium crocetinate followed by oral crocetin on contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angioplasty: A randomized placebo-controlled triple-blind clinical trial

Articles in Press, Accepted Manuscript, Available Online from 16 September 2025

Sofia Salari; AmirHooshang Mohammadpour; Arash Gholoobi; Vahid Ghavami; Javad Ramezani; Ali Eshraghi; Hossein Hosseinzadeh

Effect of hydroalcoholic extracts of Quercus brantii and Salvia officinalis on the expression of wound healing and anti-inflammatory factors in human fibroblast cells

Articles in Press, Accepted Manuscript, Available Online from 16 September 2025

Vahid Hasanvand; Mahnaz Kestami; Elham Hoveizi; Hossein Zhaleh

Review Article

Effect of flaxseed oil supplementation on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials

Articles in Press, Accepted Manuscript, Available Online from 21 September 2025

Maryam Ahmadi-khorram; Alireza Hatami; Alireza Takhttavous; Mohsen Mohammadi-Sartang; Reza Rahmanian; Sareh Dashti; Mohsen Nematy

Effect of pomegranate seed supplementation on cardiometabolic parameters: A systematic review and meta-analysis of interventional studies

Articles in Press, Accepted Manuscript, Available Online from 27 September 2025

Mostafa shahraki jazinaki; Hossein Bahari; Mohammad Reza Shadmand Foumani Moghadam; Mohammad Safarian

Impact of green tea on obesity-related hormones in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials

Articles in Press, Accepted Manuscript, Available Online from 11 October 2025

Sahar Ghoflchi; Hossein Hosseini; Sajad Rafiee; Ghader Babaei; Majid Effati; Mahdieh Aliyari; Reyhane Ghayour vatanparast; Masoud Imani; Masoumeh Rajabibazl

Original Research Article

Evaluation of the effects of Asparagus racemosus extract (ARova5X) supplementation on postmenopausal discomfort

Articles in Press, Accepted Manuscript, Available Online from 12 October 2025

Kumar Guru Mishra; Nabnita Patnaik; Adityananda Mohapatra; Nihar Ranjhan Pradhan

Review Article

Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review

Articles in Press, Accepted Manuscript, Available Online from 12 October 2025

Somaieh Sabzali; Seifollah Bahramikia; kiana Shahzamani

Effectiveness of propolis as a pulp preservation material in vital pulp therapies: A systematic review and meta-analysis

Articles in Press, Accepted Manuscript, Available Online from 12 October 2025

Mohsen Yazdanian; Mahdi Hadilou; Samira Hajisadeghi; Dara Fazlzade

Original Research Article

Protective effects auraptene alone and in combination with estradiol on intestine injury induced by traumatic brain injury in male rats: The role of oxidative stress

Articles in Press, Accepted Manuscript, Available Online from 14 October 2025

Zakieh Keshavarzi; Azadeh Seyedjoodaki; Ahmad Vosughi Motlagh; Amirreza Afshari; Fatemeh Maghool; Sedigheh Amiresmaili

Short communication

Ginger supplementation in children with oligoarticular juvenile idiopathic arthritis: A triple-blind randomized clinical trial

Articles in Press, Accepted Manuscript, Available Online from 15 October 2025

Mahsa Bozorgvar; Abbas Akhgari; Abdolreza Malek; Motahareh Boozari; Zahra Abbasi-shaye; Hossein Shahdadi Sardou; ZINAT HEIDARI

Original Research Article

Multi-target healing mechanisms of Hippobroma longiflora for diabetic wounds: A comprehensive network pharmacology study, molecular docking, and experimental insights

Articles in Press, Accepted Manuscript, Available Online from 15 October 2025

Happy Elda Murdiana; Retno Murwanti; nanang Fakhrudin; Hernawan Hernawan; Zullies Ikawati

Review Article

Anti-inflammation and antioxidant potentials of Avicennia plants: A systematic review

Articles in Press, Accepted Manuscript, Available Online from 15 October 2025

FATHIA KESUMA DINANTI; MARSETYAWAN SOESATYO; JAJAH FACHIROH; ARY SETYA HERNANDA; BENNY DIAH MADUSARI; MAE SRI HARTATI WAHYUNINGSIH

Original Research Article

Is opium use a predictor factor for major adverse cardiovascular events in coronary angiography patients?

Articles in Press, Accepted Manuscript, Available Online from 21 October 2025

Mahboobe Rafati; Mohammad Reza Khazdair; Seyyed Ali Moezi; Toba Kazemi; Nahid Azdaki; Ehsan Shirvani

Attenuation of diabetes linked testicular co-morbidity by Aloe vera: A dose-dependent transection study

Articles in Press, Accepted Manuscript, Available Online from 21 October 2025

Dibya Pal; Sukriti Hazra; Puja Das; Debidas Ghosh

Review Article

Tadābīr-i-Mashā’ikh (geriatric care‎) in Greco-Arabian (traditional) medicine: ‎‎Concept, guidelines, potential geroprotective activity, and present-day relevance

Articles in Press, Accepted Manuscript, Available Online from 22 October 2025

Sadia Nikhat; Mohammad Fazil

Original Research Article

Protective effects of saffron (Crocus sativus L.) hydro-alcoholic extract against paraquat-induced reproductive toxicity in mice

Articles in Press, Accepted Manuscript, Available Online from 22 October 2025

Shima Pedarpoor Vajargah; Farah Farokhi; Abbas Sadeghi

Evaluation of anti-gonadal activity of chloroform fraction of Thevetia peruviana leaves in male albino rats

Articles in Press, Accepted Manuscript, Available Online from 26 October 2025

Prabir Mondal; Sayandev Midya; Parag Ranjita Bera; Chhanda Mallick Mukherjee

Urolithin A safeguards against diabetes-induced pathospermia and embryotoxicity in rats

Articles in Press, Accepted Manuscript, Available Online from 26 October 2025

Haddadi-Salmasi Reza; Ahmad Gharekhani; Ali Shalizar-Jalali; Gholamreza Najafi

Short communication

Clinical and laboratory findings in patients with castor bean (Ricinus communis L.) poisoning referred to Imam Reza hospital in northeast of Iran, from April 2015 to March 2020

Articles in Press, Accepted Manuscript, Available Online from 28 October 2025

Mohammad Moshiri; Yeganeh Ramazani; Nilofar Akhgari; Bita Dadpour; Leila Etemad

Original Research Article

The effect of curcumin-piperine supplementation on liver transient elastography and biochemical indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Articles in Press, Accepted Manuscript, Available Online from 28 October 2025

Sahar Rafiee; Mohammad Bagherniya; Ziba Khoram; Amrollah Ebrahimi Varzaneh; Zahra Heidari; Thozhukat Sathyapalan; Amir Hossein Sahebkar; Gholamreza Askari

Review Article

Moringa oleifera: A promising candidate for managing metabolic syndrome

Articles in Press, Accepted Manuscript, Available Online from 01 November 2025

Amir Hossein Sahebkar; Mahboobeh Ghasemzadeh Rahbardar

Original Research Article

Therapeutic effects of Asafoetida (Ferula foetida oleo-gum-resin) on lung function tests, clinical symptoms, and blood parameters in asthmatic patients

Articles in Press, Accepted Manuscript, Available Online from 02 November 2025

Vida Hojati

Review Article

South Korean medicinal plants and their isolated phytocompounds for the management of diabetes mellitus

Articles in Press, Accepted Manuscript, Available Online from 04 November 2025

Patrick Brice Defo Deeh; Yeo Jinhee; Hye-Yong Kim; Kiseok Han; Myeong-Hyeon Wang

Original Research Article

Dorema aucheri extract for reducing oxidative stress and kidney injuries in diabetic rats

Articles in Press, Accepted Manuscript, Available Online from 12 November 2025

Alireza Raeisi,; Farhad Koohpeyma; Morvarid Siri; Hediye Fahandezh Saadi; Forough Saki; Golrokh Bahmani; Pardis Negaresh; Mesbah Shams; Sanaz Dastghaib

Micromeria biflora in alleviating hindgut mucosal injury in type 1 diabetic rats

Articles in Press, Accepted Manuscript, Available Online from 16 November 2025

Jing Zhang; Ye Wang; Lihong Chen; Zhengsheng LI; Liang Yang; Yinan Yang; Jie Xu

The antidiabetic effects of hesperidin and piperine in streptozotocin-induced diabetic rats

Articles in Press, Accepted Manuscript, Available Online from 17 November 2025

Samira Eghbali; kiana falahati; Shahnaz Rajabi; Bita Bijari; Mohammad Malekaneh

Mistletoe extract (Iscador®) in cancer patients undergoing chemotherapy for prostate and bladder tumors: A prospective observational study

Articles in Press, Accepted Manuscript, Available Online from 18 November 2025

Somaye-Sadat Heidari; Roya Ahmadi; Maryam Siavashpour; Anya Jafari; Abbas Basiri; Abolfazl Razzaghdoust; Bahram Mofid

Ameliorative effects of Spirulina on acute lead acetate toxicity complications in male rats

Articles in Press, Accepted Manuscript, Available Online from 09 December 2025

Mohammad Saroughi; Mohammad Taghi Khoshniat; Khatereh Kharazmi; Seyedeh Elnaz Nazari; Milad Bagheri; Majid Khazaei

Grape seed polyphenol extract mitigates oxidative damages induced by benzopyrene in human aortic endothelial cells by maintaining the AhR and Nrf2 signals balance

Articles in Press, Accepted Manuscript, Available Online from 10 December 2025

Man Zheng; Fenglei Zhang; Xiang Gong; Haitao Yuan

Short communication

Flavonoid intake in relation to lipid profile and fasting blood glucose: A cross-sectional analysis of the MASHHAD PERSIAN cohort study

Articles in Press, Accepted Manuscript, Available Online from 10 December 2025

Sara Ghodrat; Mostafa Shahraki Jazinaki; Reza Rezvani; Majid Khadem-Rezaiyan; Seyyed Mostafa Arabi; Saeid Eslami Hasanabadi; Mohammad Hassan Abolhassani; Seyed Mohammad Tabatabaee Jabali

Original Research Article

The hepatoprotective impacts of Citrullus colocynthis seeds extract on type 1 diabetes-induced liver inflammation and oxidative stress in rats: The role of nrf2/keap1 pathway

Articles in Press, Accepted Manuscript, Available Online from 14 December 2025

Fouzieh Salimi; Asie Sadeghi; Mohammad Abbas Bejeshk; Mohammad Amin Rajizadeh

Novel insights into the antidiabetic and antioxidant effects of Fagonia indica: A study in alloxan-induced diabetic rats

Articles in Press, Accepted Manuscript, Available Online from 21 December 2025

Hammad Ismail; Muhammad Zeeshan Bhatti; Bushra Ansari; Tayyaba Rashid; Hira Altaf; Alishwa Choudhary; Arooj Altaf; Zoima Hammad; Syed Ihtisham Haider; Abdur Rahman; Rohab Gul; Nada H. Aljarba; Ahmad H. Almehmadi; Gaber El-Saber Batiha

Investigation of the co-administration of flaxseed supplementation with high-intensity interval training, resistance training, or combined training on hematological indices and kidney health in fructose/CCl4-induced NAFLD in rats

Articles in Press, Accepted Manuscript, Available Online from 23 December 2025

Abdorreza Eghbal Moghanlou; Zahra Eslami; Merve UCA; Yusuf Can Gürsoy; Seyed Javad Mirghani

Short communication

Anticancer potential of Amygdalus scoparia bee pollen extract against prostate (PC-3) cancer cell in vitro

Articles in Press, Accepted Manuscript, Available Online from 24 December 2025

Afsaneh Ebtehaj Moghaddam; Razieh Taghavizad; Maryam Bikhof Torbati

Original Research Article

Beneficial effects of berberine and 6-gingerol against global cerebral ischemia: Insights from stereological, behavioral, and antioxidant enzyme activity

Articles in Press, Accepted Manuscript, Available Online from 28 December 2025

Dariush Mehboodi; Abbas Shahedi; Mohammad Reza Namavar; Fatemeh Rezaie; Amirmohammad Barzegari

Review Article

Plants, bacteria, fungi, and algae as biological systems for green synthesis of nanocomposites and nanomaterials: A review of current knowledge

Articles in Press, Accepted Manuscript, Available Online from 04 January 2026

Reza Mostafazade; Atena Hasanpoor; Maede Mousavi Tayyebi; Mahshad Vazirian; Negar Mousavi; Bibi Sedigheh Fazly Bazzaz

Avicenna’s foundations of traditional pharmacy and drug knowledge

Articles in Press, Accepted Manuscript, Available Online from 27 January 2026

Zahra Aghabeiglooei; jamal rezaei orimi; azam ansarifard; mahshid mafi; Roshanak Saghebi; morteza mojahedi

Original Research Article

Comparing the effects of saffron and Mucosamin® spray on oral mucositis induced by radiotherapy: A randomized controlled clinical trial

Articles in Press, Accepted Manuscript, Available Online from 31 January 2026

Fatemeh Zahra Shafiee; elham keykha; Hoda Abolhasani; samira hajisadeghi

Multitarget anticancer activity of curcumin: From docking and ADME-Tox prediction to selective cytotoxicity in triple-negative breast-cancer cells

Articles in Press, Accepted Manuscript, Available Online from 31 January 2026

Hanzla Arshad; Saif Ullah Khan; Abdul Rehman Riaz; Muhammad Muneeb; Muhammad Shahbaz Khan Afridi; Aneeqa Saleem; Maryam Khalid; Memona Khalid; Noraiz Fatima; Mirza Muhammad Tayyab Manzoor