The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study

Mohammadlo, Laila; Rahimi, Kaveh; Rezaie, Masomeh; Soufizadeh, Nasrin; Seyedoshohadaei, Fariba; Rahmani, Khaled; Bekhradi, Reza

doi:10.22038/ajp.2024.24342

The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study

Document Type : Original Research Article

Authors

Laila Mohammadlo ¹

Kaveh Rahimi ²

Masomeh Rezaie ¹

Nasrin Soufizadeh ¹

Fariba Seyedoshohadaei ¹

Khaled Rahmani ³

Reza Bekhradi ⁴

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

² Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

³ Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

⁴ Barij Medicinal Plants Research Center, Kashan, Iran

10.22038/ajp.2024.24342

Abstract

Objective: Polycystic ovary syndrome (PCOS) is a common disorder among women of reproductive age. The goal of the current study was to evaluate the effect of evening primrose oil (EPO) (Oenothera biennis) in adolescent girls with PCOS.
Materials and Methods: In the current double-blind and randomized controlled research, 76 patients completed the study in two groups (38 in the placebo and 38 in the EPO groups). The patients were asked to take oral placebo or EPO (1000 mg/day) for 12 weeks. Biochemical, clinical, and ultrasonography assessments were performed. The data was analyzed using SPSS statistical software.
Results: After the intervention, the regulation of the menstrual cycle in the EPO group was different from that of the placebo group (p=0.04). The levels of insulin, testosterone, and free androgen index (FAI) in the EPO group were lower than those of the placebo group (p<0.05). The sex hormone binding globulin (SHBG) levels in the EPO group were higher than those of the placebo group (p=0.01). While the number of immature follicles decreased in the EPO group, this difference was not statistically significant (p=0.8).
Conclusion: Overall, EPO administration for 12 weeks in young women with PCOS regulated the irregular menstrual cycle. In addition, the levels of insulin, testosterone, FAI, and SHBG changed. Therefore, EPO may be effective in improving hormonal and menstrual irregularities.

Keywords

Evening primrose oil

PCOS

Insulin

Testosterone

FAI

SHBG

Subjects