Document Type : Short communication
Authors
1
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
3
Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5
Akbar Clinical Research and Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6
Innovation and Ideation Center, Health Science and Technology Park, Mashhad University of Medical Sciences, Mashhad, Iran
7
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ajp.2025.26884
Abstract
Objective: This study aimed to investigate the effect of ginger supplementation on treatment responses in children with oligoarticular juvenile idiopathic arthritis (oligo-JIA).
Materials and Methods: A total of forty children between the ages of 6 and 16 years with oligo-JIA were randomly assigned to receive either a ginger capsule (containing 250 mg of powdered Zingiber officinale rhizomes) or a placebo twice daily for three months, along with standard treatment. The response to therapy was measured using the American College of Rheumatology Pediatric 30, 50, 70, and 90 response criteria (ACR-Pedi 30, 50, 70, and 90) after three months of supplementation.
Results: ACR-Pedi 30, 50, 70, and 90 responses were significantly higher among those receiving ginger supplement (p<0.001, p<0.001, p<0.001, and p=0.001, respectively).
Conclusion: In this study, ginger supplementation improved ACR-Pedi 30, 50, 70 and 90 responses in pediatric patients with oligo-JIA. Given its safety profile and anti-inflammatory and immunomodulatory properties, ginger supplementation may enhance therapeutic responses in this clinical setting. However, due to certain limitations within our study, further research is essential to confirm these promising findings.
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