The effect of natural adjuvants (G2, G2F) on lung inflammation of sensitized guinea pigs

Document Type : Original Research Article


1 Department of Biology, Faculty of Science, Islamic Azad University, Mashhad Branch, I. R. Iran

2 Applied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran

3 School of Public Health, Tehran University of Medical Sciences and Researches on Industrial Biotechnology, Tehran, I. R. Iran

4 Islamic Azad University, Mashhad Branch, and Zakaria Reserch Center, Mashhad, I. R. Iran

5 Faculty of Medicine, NHLI, Imperial College, London, UK


Objective: The effects of natural adjuvants were examined on total and differential WBC counts in lung lavage of sensitized guinea pigs.
Materials and Methods: In three sensitized groups of guinea pigs including: untreated sensitized animals (S), sensitized animals treated with adjuvant G2 (S+G2) and G2F (S+G2F) as well as non-sensitized group (C) (n=6 for each group), total and differential WBC counts of lung lavage were examined. Sensitization of animals was achieved by injection and inhalation of ovalbumin (OA).
Results: The results showed increased total WBC, eosinophil, neutrophil, and basophil counts, and decreased lymphocytes in lung lavage of sensitized animals compared with the control group (pConclusion: These results indicate important preventive effects of two natural adjuvants, especially G2, on lung inflammation of sensitized guinea pigs.


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