Neuroprotective, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties of Salvia Reuterana: A mini review

Document Type : Mini Review Article


1 Isfahann Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I. R. Iran

2 Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, I. R. Iran

3 Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, I. R. Iran

4 Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, I. R. Iran


Objectives: Herbal medicine is known as a valid alternative treatment. Salvia Reuterana, which has been used in the Iranian traditional medicine, is mostly distributed in the central highlands of Iran. Salvia Reuterana is a medicinal herb with various therapeutic usages. The aim of the present review is to take account of pharmacological properties of Salvia Reuterana.
Materials and Methods: The present review summarizes the literature with respect to various pharmacological properties of Salvia Reuterana.
Results: Salvia Reuterana possesses neurological, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties.
Conclusions: Salvia Reuterana can be used as an alternative for treatment of several disorders.


Main Subjects

Amirghofran Z, Zand F, Javidnia K, & Miri R. 2010. The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in Vitro Study. Ir Red Cres Med J, 12(3): 260-265.
Amiri H. 2007. Quantative and qualative changes of essential oil of Salvia bracteata Bank et Sol. in different growth stages. DARU J Pharm Sci, 15(2): 79-82.
Andalib S, Naeini A M, Vaseghi A, & Vaseghi G. 2011. Sedative and hypnotic effects of Iranian traditional medicinal herbs used for treatment of insomnia. EXCLI, 10: 192-197.
Batooli H, Safaei-Ghomi J, Haghir-Ebrahim-Abadi A, & Masoomi R. 2013. Evaluating the chemical composition of the essential oil obtained from the vegetative and reproductive organs and an antimicrobial activity of essential oil and extract of two Salvia species in Kashan region. Feyz J Kashan Uni Med Sci, 16(6): 536-545.
Eidi A, Eidi M, Mozaffarian V, & Rustaiyan A. 2012. Effect of Salvia Reuterana aerial parts on serum parameters in normal and streptozotocin-induced diabetic rats. Health Med: 1199.
Esmaeili M A, Kanani M R, & Sonboli A. 2010. Salvia Reuterana extract prevents formation of advanced glycation end products: an in vitro study. Iran J Pharm Sci, 6(1): 33-50.
Ghomi J S, Masoomi R, Kashi F J, & Batooli H. 2012. In vitro bioactivity of essential oils and methanol extracts of Salvia Reuterana from Iran. Nat Prod Com, 7(5): 651-654.
Gilhotra N, & Dhingra D. 2008. A review on antianxiety plants. Nat Prod Rad, 7( 5): 476-483.
Javidnia K, Miri R, Assadollahi M, Gholami M, & Ghaderi M. 2009. Screening of Selected Plants Growing in Iran for Antimicrobial Activity. Ir J Sci Tech, 33(A4): 229-333.
Kalia B, Kainth A, Kalia A, Kumar S, & Bhanot A. 2012. A Comprehensive Study on Anxiety: A Review. Int J Pharm Chem Sci, 1(4): 1298-1310.
Kamal M, & Jawaid T. 2011. Herbal Drugs in mirror of Anxiety Disorder-A Review. Int J  Biomed Res, 2(1): 62-72.
Karamian R, Asadbegy M, & Pakzad R. 2013. Essential oil compositions and in vitro antioxidant and antibacterial activities of the methanol extracts of two Salvia species (Lamiaceae) from Iran. Intl J Agri Crop Sci, 5(11): 1171-1182.
Masoud S, Alijanpoo B, & Khayyami M. 2011. Contribution to cytology of genus Salvia L.(Lamiaceae) in Iran. Caryologia, 64(4): 405.
Mirza M, & Sefidkon F. 1999. Essential oil composition of two Salvia species from Iran, Salvia nemorosa L. and Salvia Reuterana Boiss. Flav and Frag J, 14(4): 230-232.
Nadaf M, Nasrabadi M, & Halimi M. 2012. GC-MS Analysis of n-Hexane Extract from Aerial Parts of Salvia nemorosa. Middle-East J Sci Res, 11(8): 1127-1130.
Naser Moadeli N, Rowshan S, & A A. 2013. Comparison of the essential oil components in wild and cultivate population of Salvia virgata. J Appl Bas Sci, 4(2): 237-340.
Nickavar B. 2012. Free radical scavenging activities of four Salvia species. Res Pharm Sci, 7(5): S795.
Nickavar B, Abolhasani L, & Izadpanah H. 2010. α-Amylase Inhibitory Activities of Six Salvia Species. Iranian Journal of Pharmaceutical Research: 297-303.
Nickavar B, Kamalinejad M, & Izadpanah H. 2007. In vitro free radical scavenging activity of five Salvia species. Pak J Pharm Sci, 20(4): 291-294.
Perry N S, Bollen C, Perry E K, & Ballard C. 2003. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharm Bioch Behav, 75(3): 651-659.
Rabbani M, Sajjadi S, Jafarian A, & Vaseghi G. 2005. Anxiolytic effects of Salvia Reuterana Boiss. on the elevated plus-maze model of anxiety in mice. J Ethenopharm, 101(1): 100-103.
Rabbani M, Vaseghi G, Sajjadi S, & Amin B. 2011. Persian herbal medicines with anxiolytic properties. J Med Plants, 10(39): 7-11.
Sajjadi S E, & Shahpiri Z. 2004. Chemical composition of the essential oil of Salvia limbata CA Mey. DARU J Pharm Sci, 12(3): 94-97.
Salimpour F, Mazooji A, & Darzikolaei S A. 2011. Chemotaxonomy of six Salvia species using essential oil composition markers. J Med Plants Res, 5: 1795-1805.
Sonboli A, Babakhani B, & Mehrabian A R. 2006. Antimicrobial activity of six constituents of essential oil from Salvia. Zeitschrift fur Naturforschung C-J Biosci, 61(3-4): 160-164.
Vaseghi G, Andalib S, Rabani M, Sajjadi S, & Jafarian A. 2013. Hypnotic Effect of Salvia Reuterana Boiss for Treatment of Insomnia. J Med Plants, 12(45): 7-13.
Verma H, Verma N, Singh A, Singh M, & Singh A. 2010. Anxiolytic potential of volatile oil obtained from Ocimum Gratissimum. Deccan J Pharm, 1(2): 34-39.