Document Type : Original Research Article
Authors
1
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2
1. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran. 2. Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
3
3.Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
4
4. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
5
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical
6
6.Endocrinology and Metabolism Research Center, Institute of basic and clinical physiology sciences, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
7
7.Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Department of Physiology, Bam University of Medical Sciences, Bam, Iran
Abstract
Objective: Ulcerative colitis (UC) is a chronic, relapsing inflammatory disorder that impacts the large intestine and rectum, and it is characterized by oxidative stress and severe inflammation. Research has shown that Myrtus communis possesses antioxidative and anti-inflammatory effects. This study sought to evaluate the impact of M. communis therapy on inflammation and oxidative stress in a rat model of experimental colitis.
Materials and methods: A total of 35 male rats were selected and randomly allocated into five groups. Colitis was induced in the rats by administering a 4% acetic acid solution. Four days post-colitis induction, the rats were administered intraperitoneal treatments for the next seven days with either saline, M. communis leaves ethanolic extract (at doses of 50 and 100 mg/kg), or sulfasalazine (at a dose of 100 mg/kg).
Results: Colitis caused increased histopathological damage in the colon, along with elevated levels of Malondialdehyde, Myeloperoxidase, Tumor Necrosis Factor α,Interleukine-6 ,Interleukine-1β , and GATA-3 gene expression. Conversely, it decreased the levels of Superoxide Dismutase, Glutathione Peroxidase, IL-10, and T-bet gene expression in the treated rats compared to the control group.
Conclusion: Myrtus communis exhibits advantageous benefits on UC via reducing inflammation and oxidative stress.
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