Avicenna Journal of Phytomedicine

Avicenna Journal of Phytomedicine

Application of Thymoquinone in scaffold-based wound healing strategies: Current advances and future perspectives

Articles in Press

Document Type : Review Article

Authors
Taybeh sadat Tabatabaie 1
Mohammad Monazah 2
Neshat Ahmadi 2
Lila rezakhani 3
Alireza Masoudi 4
1 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2 2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 4. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 6. Department of pharmacology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
10.22038/ajp.2026.28101
Abstract
Abstract
Objective: Wound healing is a complex, multi-phase process that can be impaired by factors such as diabetes, infection, and oxidative stress. Among natural bioactive compounds, thymoquinone has shown considerable therapeutic potential. Therefore, this review aims to comprehensively evaluate the application of thymoquinone in scaffold-based wound healing strategies, with particular emphasis on its incorporation into biomaterial scaffolds, underlying mechanisms of action, therapeutic potential, and recent advances in tissue regeneration.
Materials and Methods: In the present study, studies on the relationship between Nigella sativa and its most important and main bioactive component, thymoquinone, in wound healing were conducted by searching Google scholar, PubMed, Science Direct and Medline Plus databases for articles published between 2001 and 2024.
Results: The evaluation of the data indicated that thymoquinone has anti-inflammatory, antioxidant and antibacterial properties and helps to improve the wound healing process.
Conclusion: The use of this substance alone or in combination with other natural healing agents is a promising approach for healing wounds, especially in conditions such as diabetes and chronic infections.
Keywords
ThymoquinoneScaffoldsWound healingNigella sativa
Subjects
Avicenna Journal of Phytomedicine

Articles in Press, Accepted Manuscript
Available Online from 15 July 2026