Objective: To explore the neuroprotective effects of Boswellia serrata and its active ingredients, boswellic acids, in the management and prevention of cerebral ischemic stroke.
Materials and Methods: A comprehensive review of both in vitro and in vivo studies was conducted to assess the efficacy of B. serrata in alleviating cerebral ischemic stroke. The mechanisms of action investigated include neuroprotection, anti-apoptotic, anti-inflammatory, and antioxidant pathways.
Results: B. serrata and the active ingredients, based on in vitro, in vivo, and limited clinical data, have shown promising results in reducing oxidative stress, inflammation, and apoptosis associated with cerebral ischemic stroke. The active compounds of B. serrata demonstrate significant neuroprotective characteristics, indicating potential therapeutic benefits.
Conclusion: While the findings highlight the potential of B. serrata as a preventive and therapeutic agent against cerebral ischemic stroke, challenges remain in translating these preclinical results into clinical practice. Further research is necessary to fully understand the mechanisms of action and any potential toxic effects on other organs, alongside the need for related clinical trial studies.