Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis

Sahebkar, Amir Hossein; Ghaemi, Fatemeh; Emadzadeh, Maryam; Almahmeed, Wael; Jamialahmadi, Tannaz; Karav, Sercan

doi:10.22038/ajp.2025.26398

Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis

Articles in Press

Document Type : Review Article

Authors

¹ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

² Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

³ Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

⁴ Department of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey

10.22038/ajp.2025.26398

Abstract

Objective: Pomegranate juice (PJ) is rich in polyphenols with potential lipid-lowering effects. This study aimed to evaluate the impact of PJ consumption on blood lipid parameters through a systematic review and meta-analysis of randomized controlled trials (RCTs).
Materials and Methods: A comprehensive literature search was conducted across multiple databases to identify RCTs assessing the effects of PJ on lipid profiles in adults. A total of 17 RCTs involving 663 participants were included. Outcomes analyzed were changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Subgroup and meta-regression analyses were performed based on dose, duration, and participant health status.
Results: PJ consumption was associated with significant reductions in TG (MD: −8.2 mg/dL) and LDL-C (MD: −4.8 mg/dL), and a significant increase in HDL-C (MD: +2.8 mg/dL). No overall effect was observed for TC. High heterogeneity was detected, partially explained by differences in PJ dose and population characteristics.
Conclusion: PJ may improve lipid profiles, particularly by reducing TG and LDL-C and increasing HDL-C levels. These effects appear more pronounced in populations with metabolic disorders. Future trials with standardized PJ formulations and longer durations are warranted.

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