Document Type : Short communication
Authors
1
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
2
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
3
Department of Clinical Pharmacy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
4
Department of Pediatrics, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
5
Department of Pediatrics, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
6
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
7
Department of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology, Vellore - 632014, India
Abstract
Objective: Allergic rhinitis is a chronic inflammatory disease
which exists throughout people's lives. Avena sativa L. (oat)
belongs to the Poaceae family and has antihistamine, antiinflammatory, and antioxidant effects. The aim of this study was to
evaluate the effects of standardized hydroalcoholic extract of oat
grains capsules as an adjunctive treatment on allergic rhinitis.
Materials and methods: Hard gelatin capsules of the dried extract
of oat grains were prepared, and characterized for key physicochemical properties. Patients diagnosed with allergic rhinitis were
recruited for the clinical trial to assess the effectiveness of these
capsules, and were randomly divided into treatment and control
groups. The participating subjects received one oat extract or
placebo capsule twice daily for two weeks. All the subjects (in the
control and treatment groups) also received oral antihistamines and
glucocorticoid nasal spray as the standard treatment. The patients’
total nasal symptom scores and the presence of allergic rhinitis
symptoms were recorded at the baseline and at the end of the second
week.
Results: After two weeks of intervention, the patients’ total nasal
symptom scores and the prevalence of allergic rhinitis symptoms
significantly decreased in all of them. However, supplementation
with oat grain extract capsules was associated with significantly
higher improvements in the outcomes in the treatment group
compared with the control group.
Conclusion: The dried extract of oat grains (Avena sativa L.)
capsules was an effective adjunctive therapy to improve allergic
rhinitis symptoms
Keywords
Main Subjects
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