Association between flavonoid intake and arterial stiffness: PERSIAN cohort study

Articles in Press

Document Type : Short communication

Authors

1 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Clinical nutrition and biochemistry department, Faculty of Medicine, Neyashbur University of Medical Sciences, Neyshabur, Iran.

4 Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5 Department of Clinical Nutrition, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

6 Department of Sports Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract

Objective: Given the growing prevalence of cardiovascular diseases (CVDs), preventing them is considered one of the most critical global health goals. Evidence suggests that high flavonoid intake may reduce the risk of CVDs. Therefore, this study investigates the association between flavonoid intake and arterial stiffness as a predictor of CVDs.
Materials and Methods: The PERSIAN cohort study in Mashhad data was used in this cross-sectional study. From data registered in the cohort center, 3423 men and women aged 35 to 70 years were recruited for this study. Total flavonoid intake and intakes of each flavonoid subclass were obtained through a food frequency questionnaire using the Phenol Explorer. Then, their association with blood pressure and arterial stiffness indices, including pulse wave velocity (PWV) and central augmentation index (AIx), was assessed using univariate logistic regression, and confounding factors were adjusted by performing the multivariable analysis.
Results: The findings showed that total flavonoid intake had a non-significant inverse relationship with high-risk levels of PWV and AIx (OR (95% CI) for the highest quintile compared to the lowest quintile were 0.83 (0.65-1.06) and 0.95 (0.74-1.21), respectively). Also, no significant association was detected between intake of each flavonoid subclass and high-risk levels of blood pressure or arterial stiffness indices including PWV and AIx.
Conclusion: This study revealed that total flavonoid and each flavonoid subclass had no significant association with high-risk arterial stiffness or blood pressure levels. More studies on flavonoids' impact on arterial stiffness are needed for a definite conclusion

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Avicenna Journal of Phytomedicine

Articles in Press, Accepted Manuscript
Available Online from 23 April 2025

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