Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial

Derakhshan, Alireza; Mirsadraee, Majid; Asnaashari, Amir-Mohammad-Hashem; Salari, Roshanak; Khadem Rezaiyan, Majid; Saeidinejat, Shahin; Jalali, Shima; Jalali, Shabnam; Ghaffari, Shadi

doi:10.22038/ajp.2025.25579

Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial

Document Type : Original Research Article

Authors

Alireza Derakhshan ¹

majid mirsadraee ²

Amir-Mohammad-Hashem Asnaashari ³

Roshanak Salari ⁴

Majid Khadem Rezaiyan ⁵

shahin saeidinejat ⁶

Shima Jalali ⁷

Shabnam Jalali ⁸

Shadi Ghaffari ⁹

¹ School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

² 3. Majid Mirsadraee, Department of Internal Medicine, Faculty of Medicine, Islamic Azad University-Mashhad Branch, Mashhad, Iran. ORCID ID:0000-0003-3420-9438. .

³ COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0003- 2960-7132.

⁴ Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

⁵ Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, iran

⁶ Department of Traditional Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁷ Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-0696-2564. Shimajalali1374@gmail.com .

⁸ Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-9093-0660.

⁹ Department of biology, Islamic Azad University- Damghan Branch,. 0000-0002-9176-8650

10.22038/ajp.2025.25579

Abstract

Objective: This study aimed to evaluate Glasthma, a Persian medicine herbal formulation for its efficacy and safety in managing asthma symptoms and modulating intestinal permeability.
Materials and Methods: Forty randomly assigned asthma patients received Glasthma syrup (n=20) or a placebo (n=20) twice daily for 4 weeks. Respiratory symptoms, pulmonary function tests, and 5-hour urine lactulose to mannitol ratio were assessed at baseline and after 4 weeks.
Results: Glasthma group exhibited significant improvements in clinical and paraclinical scores, including asthma control test (p<0.001), asthma control questionnaire 7 (p<0.007), Forced Expiratory Volume in the First Second (p<0.001), and Maximal Mid-Expiratory Flow 25-75 (p<0.002) compared to the placebo group. Lactulose and mannitol levels significantly decreased in the Glasthma group (p<0.028 and p<0.0000, respectively), with no significant changes in the ratio. No serious adverse effects were observed.
Conclusion: These findings suggest that Glasthma formulation may effectively improve asthma symptoms and regulate the gut-lung axis.

Keywords

Asthma

Intestinal permeability

Traditional Persian medicine Phytotherapy

Subjects