Document Type : Original Research Article
Authors
1
Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
2
Medical Genetics and Molecular Medicine Department, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
3
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4
Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5
Cancer, Environmental and Petroleum Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6
Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
10.22038/ajp.2025.25519
Abstract
Objective: Chronic exposure to arsenic increases the risk of type 2 diabetes. Syringic acid (SYRA) has anti-inflammatory and antidiabetic properties. The aim of this study was to investigate the effects of SYRA on sodium arsenite-induced hepatotoxicity and diabetes in mice.
Materials and Methods: Thirty male mice were divided into five groups (n=6), include control, SYRA (25 mg/kg, last week), sodium arsenite (As, 3 mg/kg for 30 days), and therapeutic groups of SYRA (10 and 25 mg/kg, last week). The mice were fasted overnight and fasting blood sugar (FBS), and glucose tolerance test (GTT) were performed. Then the mice were anesthetized, and samples of blood and liver tissue were collected for measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), thiobarbituric acid reactive substances (TBARS), total thiol, nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and caspase-3 protein expression.
Results: SYRA before As, reduced levels of liver enzymes, FBS, GTT, NO, TNF-α, and TBARS, and elevated levels of total thiol, CAT, SOD, GPx and caspase-3 expression compared to As group in mice.
Conclusion: SYRA can be suggested as a treatment option against the hepatotoxic and diabetogenic effects of As.
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