Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis

Document Type : Review Article


1 Department of Anatomy, School of Medicine, Fasa Univerity of Medical Sciences, Fasa, Iran

2 Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

3 Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

6 School of Dentistry, Shiraz university of medical science, Shiraz, Iran


 Objective: Periodontitis is a type of prevalent chronic
inflammatory disorder resulting in a failure in the function of
tissues supporting the tooth, like gingiva, alveolar bone, and
periodontal ligament. Although antibiotic therapy is a common
therapy for periodontitis cases, this approach can cause some
adverse effects in these patients. Thus, finding an effective
curative option with low side effects is still a puzzle.
Materials and Methods: This narrative review was conducted on
the effects of herbal and nano-based herbal medicine against
periodontitis by searching different databases such as Google
Scholar, PubMed, Scopus, Web of Science, Science Direct, and
Scientific Information Databases.
Results: According to published studies, some popular herbal
formulations, such as Aloe vera, curcumin, Melaleuca alternifolia,
and Scutellaria baicalensis Georgi, can be effective in periodontitis
treatment. However, these herbal products may be accompanied
by some pharmacological limitations, such as poor bioavailability,
instability, and weak water solubility. On the other hand,
harnessing nano-based herbal formulations can elevate the
bioavailability, diminish toxicity, and omit repeated administration
of drugs.
Conclusion: Herbal and nano-based herbal products can create a
good chance to treat periodontitis efficiently.


Main Subjects