Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis

Document Type : Review Article


1 Department of Anatomy, School of Medicine, Fasa Univerity of Medical Sciences, Fasa, Iran

2 Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

3 Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

4 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

6 School of Dentistry, Shiraz university of medical science, Shiraz, Iran


Objective: Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle.
Materials and Methods: This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases.
Results: According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs.
Conclusion: Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently.


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