Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial

Document Type : Short communication

Authors

1 Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

2 Department of Psychology, University of Birjand, Birjand, Iran

3 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK

4 Clinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Clinical Research Development Unit of Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Objective: Premenstrual syndrome and primary dysmenorrhea are common gynecological complaints that are associated with psychological disorders. There is increasing evidence for the neuroprotective properties of curcumin, a polyphenolic natural product. This study aimed to assess the effects of curcumin on sleep complications in women with premenstrual syndrome and dysmenorrhea.
Materials and Methods: This triple-masked, placebo-controlled clinical trial comprised 124 patients with both premenstrual syndrome and dysmenorrhea. Participants were randomly assigned to curcumin (n=57) or control (n=60) groups. Each participant received one capsule containing either 500 mg of curcumin plus piperine or placebo, daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Insomnia and sleepiness were assessed using standard questionnaires.
Results: Scores for insomnia and daytime sleepiness were directly correlated with the Premenstrual Syndrome Screening Tool (PSST) score (p<0.05), but not with the visual analogue scale (VAS) score at baseline (p>0.05). There was a non-significant reduction in insomnia and sleepiness scores in both curcumin and placebo groups after the study intervention. Whilst, improvement rate of insomnia status, daytime sleepiness severity, short sleep duration and difficult sleep initiation was not statistically significant between the curcumin and placebo groups.
Conclusion: Curcumin does not significantly affect sleep disorders in young women with premenstrual syndrome and dysmenorrhea.

Keywords


Abrahams S, Haylett WL, Johnson G, Carr JA,
Bardien S, 2019. Antioxidant effects of
curcumin in models of neurodegeneration,
aging, oxidative and nitrosative stress: a
review. Neuroscience, 406: 1-21.
Alger SE, Chambers AM, Cunningham T,
Payne JD. 2014. The role of sleep in
human declarative memory consolidation.
Curr Top Behav Neurosci, 25: 269-306.
Anand P, Kunnumakkara AB, Newman RA,
Aggarwal BB. 2007. Bioavailability of
curcumin: problems and promises. Mol
Pharm, 4: 807-818.
Aricioglu F, Cetin M. 2020. A quadruple
relationship: sleep, immune system,
inflammation and psychiatric disorders.
Psychiatry Clin Psychopharmacol, 30:
202-204.
Aşcı Ö, Gökdemir F, Süt HK, Payam F. 2015.
The relationship of premenstrual
syndrome symptoms with menstrual
attitude and sleep quality in Turkish
nursing student. J Caring Sci, 4: 179.
Ayadilord M, Mahmoudzadeh S, Hoseini ZS,
Askari M, Rezapour H, Saharkhiz M,
Abbaszadeh A, Karbasi S, Dashtebayaze
NZ, Ferns GA. 2020. Neuropsychological
function is related to irritable bowel
syndrome in women with premenstrual
syndrome and dysmenorrhea. Arch
Gynecol Obstet, 302: 915-923.
Bahrami A, Atkin SL, Majeed M, Sahebkar A.
2018a. Effects of curcumin on hypoxiainducible factor as a new therapeutic
target. Pharmacol Res, 137: 159-169.
Bahrami A, Avan A, Sadeghnia HR, Esmaeili
H, Tayefi M, Ghasemi F, Nejati
Salehkhani F, Arabpour-Dahoue M,
Rastgar-Moghadam A, Ferns GA. 2018b.
High dose vitamin D supplementation can
improve menstrual problems,
dysmenorrhea, and premenstrual
syndrome in adolescents. Gynecol
Endocrinol, 34: 659-663.
Bahrami A, Bahrami-Taghanaki H,
Khorasanchi Z, Timar A, Jaberi N,
Azaryan E, Tayefi M, Ferns GA,
Sadeghnia HR, Ghayour-Mobarhan M.
2020. Menstrual problems in adolescence:
relationship to serum vitamins A and E,
and systemic inflammation. Arch Gynecol
Obstet, 301: 189-197.
Bahrami A, Gonoodi K, Khayyatzadeh SS,
Tayefi M, Darroudi S, BahramiTaghanaki H, Eslami S, Jaberi N, Ferns
GA, Farahmand K. 2019. The association
of trace elements with premenstrual
syndrome, dysmenorrhea and irritable
bowel syndrome in adolescents. Eur J
Obstet Gynecol Reprod Biol, 233: 114-
119.
Bahrami A, Mazloum SR, Maghsoudi S,
Soleimani D, Khayyatzadeh, SS, Arekhi
S, Arya A, Mirmoosavi SJ, Ferns GA,
Bahrami-Taghanaki H, GhayourMobarhan M. 2018c. High dose vitamin
D supplementation is associated with a
reduction in depression score among
adolescent girls: a nine-week follow-up
study. J Diet Suppl, 15: 173-182.
Bahrami A, Sadeghnia H, Avan A,
Mirmousavi SJ, Moslem A, Eslami S,
Heshmati M, Bahrami-Taghanaki H,
Ferns GA, Ghayour-Mobarhan M. 2017.
Neuropsychological function in relation
to dysmenorrhea in adolescents. Eur J
Obstet Gynecol Reprod Biol, 215: 224-
229.
Bahrami A, Zarban A, Rezapour H, Agha
Amini Fashami A, Ferns GA.2021.
Effects of curcumin on menstrual pattern,
premenstrual syndrome, and
dysmenorrhea: A triple‐blind, placebo‐
controlled clinical trial. fects of curcumin
on menstrual pattern, premenstrual
syndrome, and dysmenorrhea: A triple‐
blind, placebo‐controlled clinical trial.
Phytother Res, 35:6954-6962.
Baker FC, Driver HS. 2007. Circadian
rhythms, sleep, and the menstrual cycle.
Sleep Med, 8: 613-622.
Bang JS, Choi HM, Sur BJ, Lim SJ, Kim JY,
Yang HI, Yoo MC, Hahm DH, Kim KS.
2009. Anti-inflammatory and antiarthritic
effects of piperine in human interleukin
1β-stimulated fibroblast-like synoviocytes
and in rat arthritis models. Arthritis Res
Ther, 11: R49.
Bastien CH, Vallières A, Morin CM. 2001.
Validation of the insomnia severity index
as an outcome measure for insomnia
Seyedabadi et al.
AJP, Vol. 13, No. 6, Nov-Dec 2023 594
research. Sleep Med, 2: 297-307.
Belcaro G, Cesarone M, Dugall M, Pellegrini
L, Ledda A, Grossi M, Togni S,
Appendino G. 2010. Product-evaluation
registry of Meriva®, a curcuminphosphatidylcholine complex, for the
complementary management of
osteoarthritis. Panminerva Med, 52: 55-
62.
Cappuccio FP, Taggart FM, Kandala NB,
Currie A, Peile E, Stranges S, Miller MA.
2008. Meta-analysis of short sleep
duration and obesity in children and
adults. Sleep, 31: 619-626.
Crichton N. 2001. Visual analogue scale
(VAS). J Clin Nurs, 10: 706-706.
De Craen AJ, Kaptchuk TJ, Tijssen JG,
Kleijnen J. 1999. Placebos and placebo
effects in medicine: historical overview. J
R Soc Med, 92: 511-515.
Dj B, Reynolds C, Monk T, Berman S, Kupfer
D. 1989. The Pittsburgh Sleep Quality
Index: a new instrument for psychiatric
practice and research. Psychiatry Res, 28:
193-213.
Doi Y, Minowa M, Uchiyama M, Okawa M,
Kim K, Shibui K, Kamei Y. 2000.
Psychometric assessment of subjective
sleep quality using the Japanese version
of the Pittsburgh Sleep Quality Index
(PSQI-J) in psychiatric disordered and
control subjects. Psychiatry Res, 97: 165-
172.
Dorn LD, Negriff S, Huang B, Pabst S,
Hillman J, Braverman P, Susman EJ.
2009. Menstrual symptoms in adolescent
girls: association with smoking,
depressive symptoms, and anxiety. J
Adolesc Health, 44: 237-243.
Dyawapur A, Patil NG, Metri L. 2018.
Effectiveness of cinnamon tea and
turmeric water for reducing
dysmenorrhoea among degree girls.
IJSHR, 3: 88-96.
Erbil N, Yücesoy H. 2020. Relationship
between premenstrual syndrome and
sleep quality among nursing and medical
students. Perspect Psychiatr Care, 58:
448-455
Erfanizadeh M, Noorafshan A, Namavar MR,
Karbalay-Doust S, Talaei-Khozani T.
2020. Curcumin prevents neuronal loss
and structural changes in the superior
cervical (sympathetic) ganglion induced
by chronic sleep deprivation, in the rat
model. Biol Res, 53: 31.
Fanaei H, Khayat S, Kasaeian A, Javadimehr
M. 2016. Effect of curcumin on serum
brain-derived neurotrophic factor levels in
women with premenstrual syndrome: A
randomized, double-blind, placebocontrolled trial. Neuropeptides, 56: 25-31.
Frankel RA, Michels KA, Kim K, Kuhr DL,
Omosigho UR, Wactawski-Wende J,
Levine L, Perkins NJ, Mumford SL.
2021. Serum antioxidant vitamin
concentrations and oxidative stress
markers associated with symptoms and
severity of premenstrual syndrome: a
prospective cohort study. BMC Women's
Health, 21: 49.
Ghayour Mobarhan M, Saberi-Karimian M,
Qazizadeh H, Mohammadzadeh E, AA
Ferns G, Sahebkar AH. 2021. Does
curcumin have an effect on sleep duration
in metabolic syndrome patients?
Avicenna J Phytomed, 11: 190-198.
Gozal D. 2009. Sleep, sleep disorders and
inflammation in children. Sleep Med, 10:
S12-S16.
Haghighi KS, Montazeri A, Mehrizi AK,
Aminian O, Golkhandan AR, Saraei M,
Sedaghat M. 2013. The Epworth
Sleepiness Scale: translation and
validation study of the Iranian version.
Sleep Breath, 17: 419-426.
Hatamipour M, Johnston TP, Sahebkar A.
2018. One molecule, many targets and
numerous effects: the pleiotropy of
curcumin lies in its chemical structure.
Curr Pharm Des, 24: 2129-2136.
Irwin MR. 2019. Sleep and inflammation:
partners in sickness and in health. Nat
Rev Immunol, 19: 702-715.
Johns MW. 1993. Daytime sleepiness, snoring,
and obstructive sleep apnea: the Epworth
Sleepiness Scale. Chest, 103: 30-36.
Khayat S, Fanaei H, Kheirkhah M, Moghadam
ZB, Kasaeian A, Javadimehr M. 2015.
Curcumin attenuates severity of
premenstrual syndrome symptoms: A
randomized, double-blind, placebocontrolled trial. Complement Ther Med,
23: 318-324.
Kulkarni S, Dhir A. 2010. An overview of
curcumin in neurological disorders.
Indian J Pharm Sci, 72: 149-154.
Kurotani K, Kochi T, Nanri A, Eguchi M,
Kuwahara K, Tsuruoka H, Akter S, Ito R,
Pham NM, Kabe I. 2015. Dietary patterns
Curcumin and sleep
AJP, Vol. 13, No. 6, Nov-Dec 2023 595
and sleep symptoms in Japanese workers:
the Furukawa Nutrition and Health Study.
Sleep Med, 16: 298-304.
Lopresti AL, Hood SD, Drummond PD. 2012.
Multiple antidepressant potential modes
of action of curcumin: a review of its antiinflammatory, monoaminergic,
antioxidant, immune-modulating and
neuroprotective effects. J
Psychopharmacol, 26: 1512-1524.
Maghbooli M, Safarnejad B, Mostafavi H,
Mazloomzadeh S, Ghoreishi A. 2019.
Effect of nanomicelle curcumin on quality
of life and sleep in patients with
parkinson‟s disease: a double-blind,
randomized, and placebo-controlled trial.
Int Clin Neurosci J, 6: 140-145.
Maharaj S, Trevino K. 2015. A comprehensive
review of treatment options for
premenstrual syndrome and premenstrual
dysphoric disorder. J Psychiatr Pract, 21:
334-350.
Marjoribanks J, Brown J, O'Brien PMS, Wyatt
K. 2013. Selective serotonin reuptake
inhibitors for premenstrual syndrome.
Cochrane Database Syst Rev, 2013:
CD001396.
Martinowich K, Lu B. 2008. Interaction
between BDNF and serotonin: role in
mood disorders.
Neuropsychopharmacology, 33: 73-83.
Mills PJ, von Känel R, Norman D, Natarajan
L, Ziegler MG, Dimsdale JE. 2007.
Inflammation and sleep in healthy
individuals. Sleep, 30: 729-735.
Morin CM, LeBlanc M, Daley M, Gregoire J,
Merette C. 2006. Epidemiology of
insomnia: prevalence, self-help
treatments, consultations, and
determinants of help-seeking behaviors.
Sleep Med, 7: 123-130.
Motaghinejad M, Motevalian M, Fatima S,
Faraji F, Mozaffari S. 2017. The
neuroprotective effect of curcumin
against nicotine-induced neurotoxicity is
mediated by CREB–BDNF signaling
pathway. Neurochem Res, 42: 2921-2932.
Nam GE, Han K, Lee G. 2017. Association
between sleep duration and menstrual
cycle irregularity in Korean female
adolescents. Sleep Med, 35: 62-66.
Noorafshan A, Karimi F, Kamali AM,
Karbalay-Doust S, Nami M. 2017a.
Restorative effects of curcumin on sleepdeprivation induced memory impairments
and structural changes of the
hippocampus in a rat model. Life Sci,
189: 63-70.
Noorafshan A, Karimi F, Karbalay-Doust S,
Kamali AM. 2017b. Using curcumin to
prevent structural and behavioral changes
of medial prefrontal cortex induced by
sleep deprivation in rats. EXCLI J, 16:
510-520.
Pallesen S, Sivertsen B, Nordhus IH, Bjorvatn
B. 2014. A 10-year trend of insomnia
prevalence in the adult Norwegian
population. Sleep Med, 15: 173-179.
Parry BL, Hauger R, LeVeau B, Mostofi N,
Cover H, Clopton P, Gillin JC. 1996.
Circadian rhythms of prolactin and
thyroid-stimulating hormone during the
menstrual cycle and early versus late
sleep deprivation in premenstrual
dysphoric disorder. Psychiatry Res, 62:
147-160.
Parsamanesh N, Moossavi M, Bahrami A,
Butler AE, Sahebkar A. 2018.
Therapeutic potential of curcumin in
diabetic complications. Pharmacol Res,
136: 181-193.
Saberi-Karimian M, Ghazizadeh H,
Mohammadzadeh E, Ferns GA, GhayourMobarhan M, Sahebkar A. 2021. Does
curcumin have an effect on sleep duration
in metabolic syndrome patients?
Avicenna J Phytomed, 11: 190-198.
Shafabakhsh R, Mobini M, Raygan F,
Aghadavod E, Ostadmohammadi V,
Amirani E, Mansournia MA, Asemi Z.
2020a. Curcumin administration and the
effects on psychological status and
markers of inflammation and oxidative
damage in patients with type 2 diabetes
and coronary heart disease. Clin Nutr
ESPEN, 40: 77-82.
Shechter A, Lespérance P, Kin NNY, Boivin
DB. 2012. Nocturnal polysomnographic
sleep across the menstrual cycle in
premenstrual dysphoric disorder. Sleep
Med, 13: 1071-1078.
Shoba G, Joy D, Joseph T, Rajendran MMR,
Srinivas P. 1998. Influence of piperine on
the pharmacokinetics of curcumin in
animals and human volunteers. Planta
Med, 64: 353-356.
Srinivasan K. 2007. Black pepper and its
pungent principle-piperine: a review of
diverse physiological effects. Crit Rev
Food Sci Nutr, 47: 735-748.
Seyedabadi et al.
AJP, Vol. 13, No. 6, Nov-Dec 2023 596
Steiner M, Macdougall M, Brown E. 2003.
The premenstrual symptoms screening
tool (PSST) for clinicians. Arch Womens
Ment Health, 6: 203-209.
Szmidt MK, Granda D, Sicinska E, Kaluza J.
2020. Primary dysmenorrhea in relation
to oxidative stress and antioxidant status:
A systematic review of case-control
studies. Antioxidants, 9: 994.
Vaghela N, Mishra D, Sheth M, Dani VB.
2019. To compare the effects of aerobic
exercise and yoga on Premenstrual
syndrome. J Educ Health Promot, 8: 199.
Wang Y, Gu F, Deng M, Guo L, Lu C, Zhou
C, Chen S, Xu Y. 2016. Rotating shift
work and menstrual characteristics in a
cohort of Chinese nurses. BMC women's
health, 16: 24.
Whelan AM, Jurgens TM, Naylor H. 2009.
Herbs, vitamins and minerals in the
treatment of premenstrual syndrome: a
systematic review. Can J Clin Pharmacol,
16: e407-e429.
Wichianpitaya J, Taneepanichskul S.2013. A
comparative efficacy of low-dose
combined oral contraceptives containing
desogestrel and drospirenone in
premenstrual symptoms. Obstet Gynecol
Int, 2013: 487143.
Xing X, Xue P, Li SX, Zhou J, Tang X. 2020.
Sleep disturbance is associated with an
increased risk of menstrual problems in
female Chinese university students. Sleep
Breath, 24: 1719-1727.
Yazdi Z, Sadeghniiat-Haghighi K, Zohal MA,
Elmizadeh K. 2012. Validity and
reliability of the Iranian version of the
insomnia severity index. Malays J Med
Sci, 19: 31-36.
Young TB. 2004. Epidemiology of daytime
sleepiness: definitions, symptomatology,
and prevalence. J Clin Psychiatry, 65: 12-
16.
Yu M, Han K, Nam GE. 2017. The association
between mental health problems and
menstrual cycle irregularity among
adolescent Korean girls. J Affect Disord,
210: 43-48.