Coconut oil rubbing as an easy and safe way to improve symptoms in primary nocturnal enuresis: A randomized double-blinded placebo-controlled clinical trial

Document Type : Short communication


1 Department of Persian Medicine, School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran

2 Research Center for Iranian Traditional Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Pediatrics, Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


Objective: Enuresis is a common pediatric problem for which, no unique therapy has been suggested. The conventional therapy is effective, but fails in some cases. So, many parents try complementary medicine. Therefore, this study attempted to find if rubbing coconut oil is effective on improving enuresis.
Materials and methods: This double-blinded randomized clinical was conducted on 120 children aged 6 to 14 years with mono symptomatic nocturnal enuresis, from 2018 to 2019 in Yazd, Iran. The drug and placebo groups applied 6 drops of the coconut and paraffin oil topically on the suprapubic, sacral and flanks areas one time per night, respectively. Urination pattern was daily recorded for a period of 8 weeks by parents, and after one year, they were asked for any improvement by phone call.
Results: The mean frequency of enuresis at the first, second, fourth, and eighth week was lower in the intervention group (p<0.001); this difference between the groups remained after one year. Moreover, there was no side effect requiring any medical attention.
Conclusion: Rubbing coconut oil is effective on improving symptom of primary mono symptomatic enuresis if applied every night for 4 weeks on suprapubic, sacral and flanks areas. This may be related to anticholinergic effect of the oil but its persistent effect for longer time after the end of application period, needs to be investigated in other studies.


Aghili MH. 2014. Makhzan-ol-Advieh (The
Storehouse of Medicaments) 8th Ed. In:
sabz arang (Eds), Tehran University of
Medical Sciences, pp. 781-782, Tehran.
Bronfort G, Haas M, Evans R, Leininger B,
Triano J. 2010. Effectiveness of manual
therapies: the UK evidence report. Chiropr
Osteopat, 18: 3.
Clar C, Tsertsvadze A, Hundt GL, Clarke A,
Sutcliffe P. 2014. Clinical effectiveness of
manual therapy for the management of
musculoskeletal and non-musculoskeletal
conditions: systematic review and update of
UK evidence report. Chiropr Man Therap,
22: 12.
Huang T, Shu X, Huang YS, Cheuk DK. 2011.
Complementary and miscellaneous
interventions for nocturnal enuresis in
children. Cochrane Database Syst Rev, 12:
Igboabuchi CC. 2010. Effect of coconut (cocos
nucifera) on duodenal and prostatic smooth
muscles in rabbits. PhD Thesis, University
of Nigeria Nsukka.
Instebø E, Lystad RP. 2016. Chiropractic care
of an 8-year-old girl with nonorganic,
primary nocturnal enuresis: A case report. J
Chiropr Med, 15: 47-52.
Jaradat NA, Zaid AN, Al-Ramahi R, Alqub
MA, Hussein F, Hamdan Z, Mustafa M,
Qneibi M, Ali I. 2017.
Ethnopharmacological survey of medicinal
plants practiced by traditional healers and
herbalists for treatment of some urological
diseases in the West Bank/Palestine. BMC
Complement Altern Med, 17: 255.
Lee YB, Lee JA, Jang S, Lee HL. 2018. Herbal
medicine (Suoquan) for treating nocturnal
enuresis: A protocol for a systematic review
of randomized controlled trials. Med, 97:
Ma Y, Liu X, Shen Y. 2017. Effect of
traditional Chinese and Western medicine
on nocturnal enuresis in children and
indicators of treatment success:
Randomized controlled trial. Pedia Inter, 59:
Motaharifard MS, Effatpanah M, Nejatbakhsh
Dehghanpour et al.
AJP, Vol. 12, No. 5, Sep-Oct 2022 456
F. 2020. Nocturnal enuresis in children and
its herbal remedies in Medieval Persia: A
narrative review. J Pediatr Rev, 8: 15-22.
Nevéus T, Gontard A, Hoebeke P, Hjälmås K,
Bauer S, Bower W, Jørgensen TM, Rittig S,
Walle JV, Yeung CK, Djurhuus JC. 2006.
The standardization of terminology of lower
urinary tract function in children and
adolescents: report from the Standardisation
Committee of the International Children’s
Continence Society. J Urol, 176: 314-324.
Nojavan F, Sharifi H, Ghanbari Z, Kamalinejad
M, Mokaberinejad R, Emami M. 2015.
Causes and risk factors of urinary
incontinence: Avicenna’s point of view vs.
contemporary findings. Urol J, 12: 1995-
Nørgaard J, Djurhuus J, Watanabe H, Stenberg
A, Lettgen B. 1997. Experience and current
status of research into the pathophysiology
of nocturnal enuresis. Br J Urol, 79: 825-
835. 2020. Easy bed wetting solution
for kids with bladder control issues online
available 20 april 2020 At URl:
Sellers DJ, Chess-Williams R. 2012.
Muscarinic agonists and antagonists: effects
on the urinary bladder. Handb Exp
Pharmacol, 208: 375-400.
Sharifi H, Minaie MB, Qasemzadeh MJ, Ataei
N, Gharehbeglou M, Heydari M. 2017.
Topical use of Matricaria recutita L
(Chamomile) oil in the treatment of
monosymptomatic enuresis in children: a
double-blind randomized controlled trial. J
Evid Based Complement Altern Med, 22:
Yıldırım ME, Canbal M, Ozyuvali E, Karataş
ÖF. 2016. Urological recommedations of
Hadji Pasha’s, a Turkish aged doctor in
Anatolia. Avicenna J Phytomed, 6: 502-505.