The effects of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric ulcer in male rats

Document Type : Original Research Article


1 Department of Physiology, School of Medicine, Bojnurd University of Medical Sciences, Bojnurd, I. R. Iran

2 Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran

3 Department of Physiology, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran

4 Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran


Objective: Gut–brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction.
Materials and Methods: Gastric ulcer was induced by injection of 20% acetic acid into the subserosal layer in male rats. Rats were randomly assigned into three groups: intact group, gastric ulcer group and Aloe vera group (treatment with Aloe vera following gastric ulcer induction). The acid levels and brain and intestinal water content of each sample were measured eight days after the gastric ulcer induction.
Results: Gastric acid levels were significantly decreased in Aloe vera group when compared with gastric ulcer group (p<0.05). However, there were no differences in acid output between gastric ulcer and Aloe vera groups with intact group. After Aloe vera administration, the amount of brain water content had no difference with intact and gastric ulcer groups (p<0.05). The duodenal water content in Aloe vera group was significantly reduced compared with intact group (p<0.05) but gastric ulcer group had no significant difference with intact and Aloe vera group.
Conclusions: The administration of Aloe vera has an inhibitory effect on the gastric acid output.


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