Avicenna Journal of Phytomedicine

Avicenna Journal of Phytomedicine

Antidepressant-like effect of aqueous extract from Rosa damascena in mice

Document Type : Original Research Article

Authors
Karim Dolati 1
Hassan Rakhshandeh 1
Mohammad Naser Shafei 2
1 Pharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
2 Neuroscience Research Center and Department of Physiology, School of medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
10.22038/ajp.2011.127
Abstract
Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST).
Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injected intraperitoneally. After 30 min of injection, immobility and swimming times were measured and compared with control (negative control) and imipramine (positive control).
Results: The results showed that low dose (15mg/kg) of extract significantly increased swimming time and decreased immobility time. However, the two high doses of extract (60 and 90mg/kg) had no significant effect on these parameters.
 Conclusion: These results proposed antidepressant-like effect of low concentration of aqueous extract of R. damascena.
 
Keywords
Rosa damascena
Mice
Immobility time
Antidepressant-like effect
Avicenna Journal of Phytomedicine
Volume 1, Issue 2 - Serial Number 2
September and October 2011
Pages 91-97