Document Type : Review Article
Authors
1
1. Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2. Department of Endodontics, School of Dentistry, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2
Medical Student, Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. E-mail: saberabaszade1370@gmail.com
3
Department of Pediatric, Preventive Dentistry and Orthodontics, Institute of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. E-mail: chugaeva_sechenov@inbox.ru, ORCID: 0000-0003-2854-9559
4
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran. E-mail: mohadesehkarimian18@gmail.com. ORCID: 0000-0002-8462-9118.
5
Shahrekord University of Medical Sciences
6
Professor and Vice-Chair for Research, Pediatric Clinical Pharmacology and Toxicology, Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital, One Children's Plaza, Dayton, Ohio, USA.
Abstract
Objective: Periodontitis is a prevalent oral infection with increasing global incidence. This study investigated the biological potential and therapeutic benefits of nano-curcumins (Nano-CURs) for preventing and managing dental and maxillofacial infections and their associated inflammatory complications.
Materials and methods: This systematic review followed PRISMA guidelines and included preclinical and clinical studies retrieved from PubMed/MEDLINE, Web of Science, Scopus, Embase, and the Cochrane Library before August 18, 2025.
Results: In 23 included studies, Nano-CURs mainly comprised periodontitis, gingivitis, ligature-induced periodontitis, lipopolysaccharide-induced periodontal disease, and peri-implantitis. CUR-based nanocarriers improve solubility, bioavailability, and the controlled release of the drug. These nanocarriers demonstrate potent antibacterial and antibiofilm activity against key periodontal and peri-implant pathogens. It also attenuates inflammatory signaling, decreases cytokine production and oxidative stress, and possesses favorable biocompatibility.
Conclusion: Evidence derived predominantly from preclinical studies indicates that Nano-CURs are well tolerated and may effectively inhibit dental and maxillofacial infections and associated inflammation.
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