Document Type : Original Research Article
Authors
1
Department of Traditional Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
2
Department of Internal Medicine, School of Medicine North Khorasan University of Medical Sciences, Bojnourd, Iran
3
Department of Biostatistics and Epidemiology, School of Health Health, Sciences Research Center Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
4
Assistant Professor of Nephrology Department of Internal Medicine, School of Medicine Mazandaran University of Medical Sciences, Sari, Iran
5
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6
Traditional and Complementary Medicine Research Center Addiction Institute Mazandaran University of Medical Sciences, Sari, Iran
10.22038/ajp.2026.27813
Abstract
Objective: Almonds contain healthy fats, antioxidant, and anti-inflammatory compounds that may help protect renal tissues against oxidative damage. Considering these potential nephroprotective properties, this study aimed to evaluate the effect of sweet almond capsules on kidney function in patients with chronic kidney disease (CKD).
Materials and methods: 56 patients with CKD stage 2 and 3 were randomly divided into two groups of almond capsules and placebo. The intervention was carried out for 8 weeks. In this study, glomerular filtration rate (GFR), serum creatinine (Cr), blood urea nitrogen (BUN), 24-hr urine protein, serum albumin, serum uric acid, serum potassium, blood pressure and hemoglobin, C-reactive protein (CRP), lipid profile and fasting blood sugar (FBS) were evaluated before and after the intervention.
Results: After 8 weeks of intervention, we saw an increase in GFR in the almond group compared to the control group, which was statistically significant (p=0.020). Also, FBS in the almond group was lower than the control group, and the difference between the two groups was significant (p=0.037). In the almond group, by examining the variables before and after the intervention, a significant decrease in creatinine (p=0.008) and a significant increase in GFR were observed (p=0.009). Also, high density lipoprotein (HDL) (p=0.049), and albumin (p<0.001) showed a significant increase and total cholesterol showed a significant decrease in the almond group (p=0.002).
Conclusion: Findings from this study suggest that almond consumption may have a beneficial effect on kidney function in patients with stage 2 and 3 CKD. This effect may be attributed to the reduction of blood pressure, blood glucose, serum lipids, and inflammation, as well as the protective properties of the flavonoid compounds present in almonds.
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