Boswellia serrata for the management of cerebral ischemic stroke: a preliminary review

Articles in Press

Document Type : Review Article

Authors

1 Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran

Abstract

Objective: To explore the neuroprotective effects of Boswellia serrata and its active ingredients, boswellic acids, in the management and prevention of cerebral ischemic stroke.
Materials and Methods: A comprehensive review of both in vitro and in vivo studies was conducted to assess the efficacy of B. serrata in alleviating cerebral ischemic stroke. The mechanisms of action investigated include neuroprotection, anti-apoptotic, anti-inflammatory, and antioxidant pathways.
Results: B. serrata and the active ingredients, based on in vitro, in vivo, and limited clinical data, have shown promising results in reducing oxidative stress, inflammation, and apoptosis associated with cerebral ischemic stroke. The active compounds of B. serrata demonstrate significant neuroprotective characteristics, indicating potential therapeutic benefits.
Conclusion: While the findings highlight the potential of B. serrata as a preventive and therapeutic agent against cerebral ischemic stroke, challenges remain in translating these preclinical results into clinical practice. Further research is necessary to fully understand the mechanisms of action and any potential toxic effects on other organs, alongside the need for related clinical trial studies.


Keywords

Main Subjects

Avicenna Journal of Phytomedicine

Articles in Press, Accepted Manuscript
Available Online from 23 May 2026

Files

Share

How to cite

Statistics