Document Type : Original Research Article
Authors
1
Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
3
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Applied Biomedical Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
7
Departments of Physiology, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
10.22038/ajp.2026.27578
Abstract
Objective: Inflammation is reported to have some damaging effects on liver and renal tissues. The present investigation was done to assess the liver and renal function improving effects of curcumin (Cur) in a systemic inflammation model induced by lipopolysaccharide (LPS) in rats.
Materials and Methods: Thirty five rats (male) were assigned to five groups: Control, LPS injected group (1 mg/kg, intraperitoneal), and three Cur-treated groups (5-15 mg/kg, oral, 14 days) plus LPS. Serum biochemical indicators including alkaline phosphatase (ALKP), aspartate aminotransferase (AST), total protein, alanine aminotransferase (ALT), creatinine, and blood urea nitrogen (BUN) for liver and kidney function were measured. Oxidative stress markers and inflammation indicator (interleukin-6 (IL-6)) were also measured in the liver and renal tissues.
Results: An inflammation status was seen in the liver and kidney after LPS injection presented by increased levels of IL-6. It was also accompanied with increasing serum level of ALKP, AST, ALT, BUN, and creatinine and a decrease in total protein. Pre-treatment with Cur restored liver and kidney function markers. In addition, LPS injection was accompanied by enhancement of the level of malondialdehyde (MDA) and IL-6 in both liver and kidney tissues while decreased levels of total thiol, superoxide dismutase (SOD), and catalase. Administration of Cur before LPS attenuated the level of MDA and IL-6 while increasing total thiol content and SOD and catalase activities.
Conclusion: Curcumin confers hepatic and renal protective effects against LPS-mediated toxicity, likely attributable to its antioxidant and anti-inflammatory mechanisms.
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