Document Type : Original Research Article
Authors
1
Pharmacognozy
2
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4
Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5
Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
6
Department of Biostatistics, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
8
Department of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9
Deputy for The Secretariat of the Council for Basic Medical Sciences, Health and Graduate’s Education, Treatment and Medical Sciences, Ministry of Health, Tehran, Iran
10
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Objective: To investigates the effects of rosehip alcoholic extract on chest pain severity and echocardiographic parameters in patients with coronary slow flow (CSF).
Materials and Methods: Thirty patients presenting CSF in the left anterior descending (LAD) artery were randomly allocated into two groups of rosehip and placebo for eight weeks. Echocardiographic parameters and Canadian Cardiology Society (CCS) angina scores were evaluated at baseline and at the end of the study.
Results: Significant increases were observed in peak diastolic velocity (PDV), mean diastolic velocity (MDV), and velocity time integral (VTI) within the rosehip group as compared to control group (p=0.001, 0.006, and 0.020, respectively). Comparative analysis of echocardiographic parameters between the two groups demonstrated significant improvements in PDV and MDV in the rosehip group (p=0.031 and 0.003, respectively). Nonetheless, differences in PDP, MDP, VTI, and Dint between the two groups were not statistically significant. Furthermore, chest pain was significantly alleviated in the rosehip group (p=0.015).
Conclusion: Rosehip supplementation enhances microvascular coronary blood flow and diminishes chest pain in patients with CSF.
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