Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis

Document Type: Original Research Article

Authors

1 DM College of Pharmacy, Bahadurgah, Haryana, India.

2 Deptt. of Pharmaceutical Sciences, Jamia Hamdard, New Delhi, India.

3 Seoul National University, Republic of Korea, Korea.

4 Division of Pharmaceutics, Faculty of Medical Sciences, Lovely Professional University, Phagwara, Punjab India.

5 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

Abstract

Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis).
Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer.
Results: Among the fractions POR showed better activity.  POR and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test POR significantly (p < 0.05) reduced abdominal writhes than PE.  In hot plate method POR showed better analgesic activity than PE. POR showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE.
Conclusions: The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.

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Main Subjects


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