1Agricultural Research Center, High Educational complex of Saravan, I. R. Iran
2Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
3Department of Biology, University of Sistan & Baluchestan, Zahedan, I. R. Iran
Abstract Objective: The current study summarizes the updated information concerning the ethnopharmacology, Phytochemistry, and pharmacology of Otostegia persica Boiss. (Lamiaceae), an endemic medicinal plant in south and southeast of Iran. Materials and Methods: Information was collected through bibliographic investigation from scientific journals, books, theses, reports, and electronic search (databases SCOPUS, Google Scholar, Web of Science, and Science Direct). Moreover, documentation from unpublished resources and ethnobotanical surveys has been used. The present review covers the literature available from 2003 to 2013. Results: In traditional systems of medicine, this plant is reputed for treating diabetes, arthritis, gastric discomfort, headache, rheumatism, sedative activities, regulating blood pressure, and hyperlipidemia. Phytochemical screening of active components and mineral element evaluation of this species have been reported. Several types of diterpenoids and flavonols including morin, kaempferol, and quercetin are identified from the plant. Most of the pharmacological activity of this plant resides in its ﬂavonoid fraction which causes antimicrobial and antioxidant activities. Various pharmacological studies on O. persica show antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, anti-aphid, and hepatoprotective activities. Conclusion: Being an endemic plant of Iran, this species is an important medicinal herb which can be used for various purposes. This review might be helpful for scientists and researchers to find new chemical entities responsible for its claimed traditional uses and discover new lead compounds for diseases mentioned.
Adewole SO, Caxton-Martins EA, Ojewole JAO. 2007. Protective Effect of Quercetin on the Morphology of Pancreatic β-Cells of Streptozotocin-Treated Diabetic Rats. Afr J Tradit Complement Altern Med, 4: 64-74.
Akbarzadeh S, Bazzi P, Daneshi A, Nabipour I, Pourkhalili Kh, Mohebbi Gh, Sartavi K, Abdi M, Mirzaei M, Bargahi A. 2012. Anti-diabetic effect of Otostegia persica extract on diabetic rats. J Med Plant Res, 6: 3176-3180.
Asghari G, Nourallahi H, Havaie SA, Issa L. 2006. Antimicrobial activity of Otostegia persica Boiss. extracts. Res Pharm Sci, 1: 53-58.
Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL. 2005. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes, 54: 97-107.
Ebrahimpoor MR, Khaksar Z, Noorafshan A. 2009. Antidiabetic Effect of Otostegia persica Oral Extract on Streptozotocin- Diabetic Rats. Res J Biol Sci, 4: 1227-1229.
Ganjali A, Sotoudeh A, Jahanshahi A, Ashrafzadeh TakhtfooladiM, Bazzazan, A, RoodbariN, Pourramezani Harati M. 2013. Otostegia persica extraction on healing process of burn wounds. Acta Cirurgica Brasileira, 28: 407.
Ghahraman, A. 1996. Color Atlas of Iranian Flora, Research Institute of Forests and Rangelands Publishing, Tehran, Iran, Iran University Press.
Ghahraman, A. 1993. Plant Systematics; Cormophytes of Iran, pp. 359-366, Tehran-Iran, Iran University Press.
Ghanbarian GhA, Jafari E, Hatami A. 2011. Presentation of flora, life forms and chorology of plant species in the Jahrom area (Fars Province, Iran), IUFS J Biol, 70: 1-12.
Hajhashemi V, Rabbani M, Asghari GR, Karami-Saravi Z. 2004. Effects of Otostegia persica (Burm.) Boiss on morphine withdrawal syndrome in mice. Iran J Pharm Res, 3: 171-175.
Javidnia K, Miri R, Soltani M, Khosravi AR. Chemical constituents of the essential oil of Otostegia Michauxi Briq. from Iran. 2007, The 8th Annual Research Congress of Iranian Medical Sciences Students & 1st International Student Congress on Medical Research Shiraz, Iran.
Kannappan S, Anuradha CV. 2009. Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model. Indian J Med Res, 1294: 401-408.
Khan A,Ahmad VU,Farooq U,Bader S, Arshad S. 2009. Two New Flavonol Glycosides from Otostegia limbata BENTH.Chem Pharm Bull, 57: 276-279.
Mahmoody SM. 2007. Phytochemical Study of Essential Oil of Otostegia persica by GC-Mass and Investigation of its Methanol Extract. MSc, Kerman University of Medical Sciences, Kerman, Iran.
Manzari-Tavakoli A, Pouraboli I, Yaghoobi MM, Mehrabani M, Mirtadzadini SM. 2013. Antihyperglycemic, antilipid peroxidation, and insulin secretory activities of Otostegia persica shoot extract in streptozotocin-induced diabetic rats and in vitro C187 pancreatic β-cells. Pharm Biol, 51:253-259.
Matsuoka KNT, Nakamura A, Honda C, Endo K, Tsukada M. 2008. Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. Chem Phys Lipids, 1542: 87-93.
Naghibi F, Mosaddegh M, Mohammadi S, Ghorbani A. 2005. Labiatae Family in folk Medicine in Iran: from Ethnobotany to Pharmacology. Iranian J Pharm Res, 2: 263-79.
Nasir E, Ali SI. 1879. Flora of Pakistan, Otostegia persica (Burm. f.) Boiss., pp. 347.
Nateghpour M, Farivar L, Souri E, Hajjaran H, Mohebali M, Motevalli Haghi A. 2012. The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method. Iran J Pharm Res, 11: 583-588.
Sadeghi Z. 2010. Phytochemical and Antimicrobial Investigation of Otostegia persica and Otostegia aucheri, from Saravan region. MSc, Sistan and Baluchestan University, Iran.
Sadeghi Z, Kuhestani K, Abdollahi V. 2013. Indigenous knowledge of medicinal plants: An approach to sustainable development of Baluchistan region. 1st national conference on solutions to access sustainable development in agriculture, natural resources and the environment. Tehran, Iran.
Safa O, Soltanipoor MA, Rastegar S, Kazemi M, Nourbakhsh Dehkordi K, Ghannadi A. 2013. An ethnobotanical survey on hormozgan province, Iran. Avicenna J Phytomed, 3: 64-81.
Salari E, Ahmadi K, Zamani, R. 2010. Study on the Effects of Acetonic Extract of Otostegia Persica (Labiatae) on Three Aphid Species and One Stored Product Pest. Adv Environ Biol, 4: 346-349.
Sharififar F, Mozaffarian V, Moradkhani S. 2007. Comparison of antioxidant and free radical scavenging activities of the essential oils from flowers and fruits of Otostegia persica Boiss. Pak J Biol Sci, 10: 3895-3899.
Shrififar F, Yassa N, Shafiee A. 2003. Antioxidant Activity of Otostegia persica (Labiatae) and its constituents. Iran J Pharm Res, 2: 235-239.
Tofighi Z, Alipour F, Goodarzi S, Yassa N, Hadjiakhoondi A, Hadavinia H. 2009. Phytochemical and antidiabetic investigations of Otostegia persica from Iran. Planta Medica, 9: 1013-1014.