TY - JOUR ID - 19620 TI - Nephroprotective activity of naringin against chemical-induced toxicity and renal ischemia/reperfusion injury: A review JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Amini, Negin AU - Maleki, Maryam AU - Badavi, Mohammad AD - Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran AD - Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran Y1 - 2022 PY - 2022 VL - 12 IS - 4 SP - 357 EP - 370 KW - Kidney KW - Naringin KW - Oxidative stress KW - Toxicity DO - 10.22038/ajp.2022.19620 N2 - Objective: The kidney is well-known as the vital organ which is responsible for maintaining body homeostasis and secretion of toxic metabolites. Renal injury is accompanied by oxidative stress which results in cellular apoptosis, lipid peroxidation, and reduction of antioxidant levels. Plant extracts and their phytoconstituents, owing to free radical scavenging properties, seem to be valuable against modern synthetic and chemical drugs. Naringin is a flavonoid present in citrus fruits with pharmacologic effects including antioxidant, anti-inflammatory, and anti-apoptotic properties. This review summarizes the renoprotective effects of naringin and discusses mechanisms of its action against renal injury.Materials and Methods: For this paper, original subject-related articles published up to October 2020 have been reviewed in the databases, including PubMed, Scopus, and Web of Science, and Google Scholar.Results: Naringin increases antioxidant enzyme activity, and glutathione content, reduces lipid peroxidation and inhibits inflammatory cytokines. In the molecular investigation, naringin activates the Nrf-2 signaling, prevents apoptosis signaling, and inhibits the autophagy pathway. Besides, naringin could protect the kidney through modulating microRNA-10a in the kidney tissue in an acute kidney injury model.Conclusion: This review recommends that naringin can be considered a promising candidate to treat kidney dysfunction induced by oxidative stress in the future. UR - https://ajp.mums.ac.ir/article_19620.html L1 - https://ajp.mums.ac.ir/article_19620_39dfb5af7aaed178b2d1a369496dadfb.pdf ER -