Possible potential of Astrodaucus genus in development of anticancer drugs

Document Type : Review Article

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

2 Departments of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

3 Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Objective: Many pharmaceutical factories have dramatically improved the quality of herbal remedies in cancer treatment. The results of somestudies have shown anticancer effect of Astrodaucus genus. Therefore, the aim of this article was to review the chemical ingredients and biological effects of Astrodaucus genus especially A. persicus from the family Apiaceae (Umbelliferae).
Materials and Methods: Online databases ScienceDirect, PubMed, Scopus, and Google Scholar were searched using the keywords Astrodaucus, Apiaceae, Biologic, Phytochemistry, and Benzodioxole to retrieve studies published between 1970 and 2020.
Results: The Astrodaucus genus has two species, Astrodaucus persicus (Boiss.) Drude and Astrodaucus orientalis (L.) Drude. In this genus, 5 new biologically active phytochemicals with benzodioxole structure were introduced and their biological effects were assessed.
Conclusion: Since many of the most commonly used anticancer drugs such as etoposide, teniposide, podophyllotoxin and sanguinarine have benzodioxole structureand according to the results of biological tests, it seems that more researchwith these perspectives should be done on this genus.

Keywords


Abas F, Khatib A, Shaari K, Shaari K,
Lajisae NH, Maulidiani. 2014. Chemical
characterization and antioxidant activity of
three medicinal Apiaceae species. Ind Crops
Prod, 55: 238-247.
Abdolmohammadi MH, Fouladdel SH, Shafiee
A,Amin Gh, Ghaffari SM, Azizi E. 2008.
Anticancer effects and cell cycle analysis on
human breast cancer T47D cells treated with
extracts of Astrodaucus persicus (Boiss.)
Drude in comparison to doxorubicin.
DARU, 16: 112-118.
Abdolmohammadi M, Fouladdel S,Shafiee A,
AminGh,Ghaffari SM,Azizi E. 2009.
Antiproliferative and apoptotic effect of
Astrodaucus orientalis (L.) drude on T47D
human breast cancer cell line: Potential
mechanisms of action. Afr J Biotechnol, 8.
Amiri, M., Joharchi, M. 2016 . Ethnobotanical
knowledge of Apiaceae family in Iran: A
review. Avicenna J, 6, 621-635.
Azizi E, Abdolmohammadi MH, Fouladdel SH,
Shafiee A, Amin GH, Ghaffari SM. 2015.
Evaluation of p53 and Bcl-2 genes and
proteins expression in human breast cancer
T47D cells treated with extracts of
Astrodaucus persicus (Boiss.) Drude in
comparison to Tamoxifen. DARU, 17: 81-
186.
BalunasMJ, Kinghorn AD. 2005. Drug
discovery from medicinal plants. Life Sci,
78: 431-441.
Barnard C, Padgitt M, Uri N. 1997. Pesticide
use and its measurement. Int. Pest Control,
39: 61-164.
Bauer JH, Helfand SL. 2006. New tricks of an
old molecule: lifespan regulation by p53.
Aging cell, 5: 437-440.
Bazargani, Y, Almasirad A, Amin G, Shafiee
A. 2006. Chemical composition of the
essential oils of Astrodaucus persicus
(Boiss.) Drude root, stem/leaves and
flowers/fruits. Flavour Fragr J, 21: 294-296.
Bigdeli M, Abdolhossein R, Ameri N,
Masoudi S. 2004. Essential Oil of
Astrodaucus persicus (Boiss.) Drude. from
Iran. J Essent Oil Res,16: 420-421.
Bouchekrit M, Laouer H, Hajji M, Nasri M,
Haroutounian SA, Akkal S. 2016. Essential
oils from Elaeoselinum asclepium:
Chemical composition, antimicrobial and
antioxidant properties. Asian Pac. J. Trop.
Biomed, 6: 851-857.
Buchanan RL. Toxicity of spices containing
methylenedioxybenzene derivatives: a
review. J Food Saf, 1978. 1: 275-293.
Chen WF, Huang MH, Tzang CH, Yang M,
Wong MS. 2003. Inhibitory actions of
genistein in human breast cancer (MCF-7)
cells. BBA-Mol Basis Dis, 1638: 187-196.
Chen YF, Lin YC, Huang PK, Chan HC,
Kuo SC. 2013. Design and synthesis of
6,7-methylenedioxy-4-substituted
phenylquinolin-2(1H)-one derivatives as
novel anticancer agents that induce
apoptosis with cell cycle arrest at G2/M
phase,Bioorg Med Chem, 21, 5064-5075.
Chiang SY, Lee PY, Lai MT, Shen LC, Chung
WS, Huang HF, Wu KY, Wu HC.2011.
Safrole-2′, 3′-oxide induces cytotoxic and
genotoxic effects in HepG2 cells and in
Anticancer potential of Astrodaucus genus
AJP, Vol. 11, No. 1, Jan-Feb 2021 19
mice. Mutat Res Genet Toxicol Environ
Mutagen, 726: 234-241.
Cragg GM, Newman DJ. 2005. Plants as a
source of anti-cancer agents. J
Ethnopharmacol, 100: 72-79.
Danciu C, Avram S, Gaje P, Pop G, Şoica
C, Craina M, Dumitru C, Dehelean C,
Peev C. 2013. An evaluation of three
nutraceutical species in the Apiaceae family
from the Western part of Romania:
antiproliferative and antiangiogenic
potential. J Agroalimentary Processes
Technol, 19: 173-9.
Dawood R,Solaiman A. 2019. Synthesis and
characterization of new 1,3-benzodioxole
derivatives based on Suzuki-Miyaura
coupling reaction. Res J Chem Environ, 23:
14-21.
Dobashi Y, Takehana T, Ooi A. 2003.
Perspectives on Cancer Therapy: Cell Cycle
Blockers and Perturbators. Curr Med
Chem, 10: 2549-2558.
Fatope M, Ibrahim H, Takeda Y. 1993.
Screening of higher plants reputed as
pesticides using the brine shrimp lethality
assay. IJPR, 3: 250-254.
Emami S, Aghazari F. 2010. Iranian endemic
phanerogams. Iran J Pharm Res, 62-63.
Gasco M, Crook T. 2003. p53 family members
and chemoresistance in cancer: what we
know and what we need to know. Drug
Resist Updat, 2003. 6: 323-328.
Goodarzi S, Hadjiakhoondi A, Yassa N,
Khanavi M, Tofighi T. 2016a. Essential oils
chemical composition, antioxidant activities
and total phenols of Astrodaucus persicus.
IJBMS, 19: 159.
Goodarzi S, Hadjiakhoondi A, Yassa N,
Khanavi M, Tofighi T.2016b. New
benzodioxole compounds from the root
extract of Astrodaucus persicus. Iranian
journal of pharmaceutical research: IJPR,
15: 901.
Goodarzi S, Vatandoost H, Abai MR, Tavakoli
S, Hatamian A, Ajani Y, Hadjiakhoondi A,
Yassa N, Tofighi T. 2017. Astrodaucus
persicus as a new source of bioinsectisides
against malaria vector, Anopheles stephensi.
Asian Pac J Trop Med,10: p. 896-899.
Gupta A, Khan S, Muzafar M, Yadav AK,
Sharma G, Anand R. 2017. Anticancer
curcumin: natural analogues and structureactivity relationship, in Studies in natural
products chemistry. Elsevier. 355-401
Gupta SC1, Kim JH, Prasad S, Aggarwal BB.
2010. Regulation of survival, proliferation,
invasion, angiogenesis, and metastasis of
tumor cells through modulation of
inflammatory pathways by nutraceuticals.
Cancer Metastasis Rev, 29: 405-434.
Gupta SD, Rao GB, Bommaka MK, Bommaka
MK, Raghavendra NM, Aleti S. 2016. Ecosustainable synthesis and biological
evaluation of 2-phenyl 1, 3-benzodioxole
derivatives as anticancer, DNA binding and
antibacterial agents. Arab J Chem, 9:
S1875-S1883.
Hadjiakhoondi A, Vatandoost H, Khanavi M.
Abaee MR, Karami M.2005. Biochemical
investigation of different extracts and
larvicidal activity of Tagetes minuta L. on
Anopheles stephensi larvae. Iran J Pharm
Sci, 1: 81-84.
HoussamiN, Macaskill P, Marinovich ML,
Dixon JM, Irwig L, Brennan ME , Solin
LJ.2010. Meta-analysis of the impact of
surgical margins on local recurrence in
women with early-stage invasive breast
cancer treated with breast-conserving
therapy. Eur J Cancer, 46: p. 3219-3232.
Hsuuw YD, Chan WH. 2015. Apoptotic
effects of dillapiole on maturation of mouse
oocytes, fertilization and fetal development.
Drug Chem Toxicol, 38: 469-476.
IngvarssonS. 2001. Breast cancer: introduction.
in seminars in CANCER BIOLOGY. 2001.
Academic Press
James AA. 1992. Mosquito molecular genetics:
the hands that feed bite back. Science, 257:
37-39.
Krajewski S, Krajewski M, Turner BC, Pratt C,
Howard B , Zapata JM, Frenkel V,
Robertson S, Ionov Y, Yamamoto H,
Perucho M, Takayama S, Reed JC.1999.
Prognostic significance of apoptosis
regulators in breast cancer. Endocr Relat
Cancer, 6: 29-40.
Lee KH. 1999. Novel antitumor agents from
higher plants. Med Res Rev, 19: 569-596.
Masoudi S, Fathollahi R, Taherkhani
M,Valadkhani Z, Baradari T, Cheraghi M,
Rustaiyan A. 2012. Volatile Constituents of
the Aerial parts of Torilis leptophylla (L.)
Reichenb., Thecocarpus meifolious Boiss.,
Leaves of Xanthogalum purpurascens Ave.
Lall. and Flowers of Astrodaucus orieintalis
(L.) Drude. Four Umbelliferae Herbs from
Iran. J Essent Oil-Bear Plants, 15: 934-942.
Mazloomifar H, Bigdeli M, Saber-Tehrani
M,Rustaiyan A, Masoudi S. 2003. Essential
Ghorbani Hesari et al.
AJP, Vol. 11, No. 1, Jan-Feb 2021 20
Oil of Astrodaucus orientalis (L.) Drude.J
Essent Oil Res, 2003. 15: 254-255.
Mirza M, Baher Nik Z, Dini M. 2003.
Chemical composition of the essential oils
of Astrodaucus orientalis (L.) Drude leaves
and seeds. Flavour and fragrance journal,
18: p. 205-206.Mozaffarian V. 2007. Flora
of Iran: Umbelliferae. Research Institute of
Forests and Rangelands.
Moreira DR, Lima Leite AC, Pinheiro Ferreira
PM, et al. 2007. Synthesis and antitumour
evaluation of peptidyl-like derivatives
containing the 1, 3-benzodioxole system.
Eur J Med Chem, 42: 351-357.
Naddaf SR, Oshaghi MA, Vatandoost H,
Assmar M. 2003. Molecular
characterization of Anopheles fluviatilis
species complex in the Islamic Republic of
Iran. EMHJ, 9, 257-265.
Nagpal B, Sharma V. 1995. Indian
Anophelines. 66 Janpath, New Delhi
110001: Mohan Primlani for Oxford & IBH
Publishing Co. Pvt. Ltd.
NathanSS. 2007. The use of Eucalyptus
tereticornis Sm.(Myrtaceae) oil (leaf
extract) as a natural larvicidal agent against
the malaria vector Anopheles stephensi
Liston (Diptera: Culicidae). Bioresour
Technol, 98: 856-1860.
Nazemiyeh H, Razavi SM,
DelazarA,Asnaashari S, Seyedkhoei N,
Daniali S, Nahar L, Sarker S. Distribution
Profile of Volatile Constituents in Different
Parts of Astrodaucus orientalis (L.) Drude.
Rec. Nat Prod, 3.
PaeHO, Hyuncheol Oh, Yun YG, Oh GS, Jang
SLL, Hwang KS, Kwon O, Lee HS, Chung
HT. 2002. Imperatorin, a furanocoumarin
from Angelica dahurica (Umbelliferae),
induces cytochrome c‐dependent apoptosis
in human promyelocytic leukaemia, HL‐60
cells. Pharmacol Toxicol, 91: 40-48.
PrabuseenivasanS, Jayakumar M, Ignacimuthu
S. 2006. In vitro antibacterial activity of
some plant essential oils. BMC Complement
Altern Med, 6: 39.
Ramos S. 2007. Effects of dietary flavonoids on
apoptotic pathways related to cancer
chemoprevention. J Nutr Biochem, 18: 427-
442.
Rebey IB, Zakhama N, Karoui IJ, Marzouk B.
2012. Polyphenol composition and
antioxidant activity of cumin (Cuminum
cyminum L.) seed extract under drought. J
Food Sci, 77: C734-C739.
Srivastava V, Neg AS, Kumar JK, Gupta MM,
Khanuja PS. 2005. Plant-based anticancer
molecules: a chemical and biological profile
of some important leads. Bioorg Med
Chem, 13: 5892-5908.
Tan ML, Sulaiman SF, Najimuddin N, Samian
MR,Tengku Muhammad TS.2005.
Methanolic extract of Pereskia bleo (Kunth)
DC.(Cactaceae) induces apoptosis in breast
carcinoma, T47-D cell line. J
Ethnopharmacol, 96: 287-294.
Taraphdar AK, Roy M, Bhattacharya R. 2001.
Natural products as inducers of apoptosis:
Implication for cancer therapy and
prevention. Current science, 1387-
1396.
Torabbeigi M, Azar PA, Sharifan A,
AghaeiMeibodi Z. 2012. Antibacterial
activity and comparison of the volatile
constituents obtained by several extraction
methods from the flowers, stems and leaves
of Astrodaucus orientalis. Nat Prod
Commun. 7: 1934578X1200700236.
Torre LA, Trabert B, DeSantis CE,Kimberly
D, Carolyn D, Ahmedin J,Rebecca L.. 2018.
Ovarian cancer statistics, CA Cancer J Clin,
68: 284-296.
Tuorkey J. 2014. Curcumin a potent cancer
preventive agent: Mechanisms of cancer cell
killing. Interv Med Appl Sci, 6: 139-146.
Vatandoost H, Khazani A, Rafinejad J,
Khoobdel M, Kebriai-Zadeh A, Abai MR,
hanafi-bojd AA, Akhavan AA, Abtahi SM,
Rafi F.2008. Comparative efficacy of neem
and dimethyl phthalate (DMP) against
malaria vector, Anopheles stephensi
(Diptera: Culicidae). Asian Pac J Trop Med.
1: 1-6.
Wang HH, Qiu KM, Cui HE, Yang YS, Xing
M, Qiu XY, Bai LF,Zhu HL.2013.Synthesis,
molecular docking and evaluation of
thiazolyl-pyrazoline derivatives containing
benzodioxole as potential anticancer agents.
Bioorg Med Chem.21: 448-455.
Wang H, Zhang Y, Xie LP,Yu XY, Zhang RQ.
2002. Effects of genistein and daidzein on
the cell growth, cell cycle, and
differentiation of human and murine
melanoma cells. J Nutr Biochem. 13: 421-
426.
Wong RS. 2011. Apoptosis in cancer: from
pathogenesis to treatment. J Exp Clin
Cancer Res, 30: 87.
Zhang YH, Park YS, Kim TJ, Fang LH,Ahn
HY, Hong JT, Kim Y, Lee CK, Yun YP.
Anticancer potential of Astrodaucus genus
AJP, Vol. 11, No. 1, Jan-Feb 2021 21
2000. Endothelium-dependent vasorelaxant
and antiproliferative effects of apigenin.
Vasc Pharmacol, 35: 341-347.