TY - JOUR ID - 18001 TI - Neuroprotective effects of Coriandrum sativum and its constituent, linalool: A review JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hosseini, Mahmoud AU - Boskabady, Mohammad Hossein AU - khazdair, Mohammad Reza AD - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Y1 - 2021 PY - 2021 VL - 11 IS - 5 SP - 436 EP - 450 KW - Coriandrum sativum L KW - neuro-pharmacological effects KW - memory impairment KW - Linalool DO - 10.22038/ajp.2021.55681.2786 N2 - Objective: Coriander (Coriandrum sativum L.) is an annual herb belonging to the Apiaceae (Umbellifera) family that is used as food additives traditionally. This plant is called “Geshniz” in Persian and is native to Mediterranean regions but it is currently cultivated in several countries. All parts of coriander are edible and have been traditionally used to treat different disorders, including digestive problems, flatulence, diarrhea, colic and other gastrointestinal diseases.Materials and Methods: The databases PubMed, Web of Science, Google Scholar and Scopus were considered. The search terms were “Coriandrum sativum” or “linalool” and “anti-anxiety”, “sedative”, “antioxidant effect”, “anticonvulsant” and “neuroprotective effect”.Results: Antioxidant, diuretic, cholesterol lowering, anxiolytic, sedative-hypnotic and anticonvulsant activities were reported for the seeds and leaves of the plant. Furthermore, linalool as the main component of coriander has different neuropharmacological effects, including anti-anxiety, sedative, anticonvulsant and anti-Alzheimer’s disease activities.Conclusion: Various neuropharmacological effects of C. sativum and its component which have antioxidant and anti-inflammatory effects, have been summarized in the current review article. UR - https://ajp.mums.ac.ir/article_18001.html L1 - https://ajp.mums.ac.ir/article_18001_c1de9eee9b56b0c27a5cfff875c4f8c2.pdf ER -