TY - JOUR ID - 18037 TI - Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κB pathway JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Rashidian, Amir AU - Akbarzadeh, Dorna AU - Asgarpanah, Jinous AU - Dehpour, Ahmadreza AD - Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Y1 - 2021 PY - 2021 VL - 11 IS - 5 SP - 505 EP - 514 KW - Bunium persicum essential oil KW - Ulcerative colitis KW - Acetic acid KW - NF-kB DO - 10.22038/ajp.2021.18037 N2 - Objective: The aim of this study was to evaluate the anti-inflammatory effect of B. persicum essential oil on colonic inflammation and the role of suppression of NF-κB pathway in rat colitis induced by acetic acid solution.Materials and Methods: Induction of acute colitis was done by intra-luminal instillation of 2 ml of acetic acid (4%) diluted in normal saline. Two hours after colitis induction, 0.2% tween 80 in normal saline, prednisolone (4 mg/kg) or B. persicum essential oil (100, 200, and 400 mg/kg) were administered to the rats orally and continued for 5 consecutive days. The severity of macroscopic and microscopic damages was assessed. Myeloperoxidase and TNF-α activity was evaluated by biochemical analysis and ELISA respectively and protein expression of p-NF-κB was assessed by immunohistochemistry (IHC).Results: Prednisolone and B. persicum essential oil (100, 200, and 400 mg/kg) decreased macroscopic and microscopic injuries compared to the acetic acid group. On the other hand, prednisolone and B. persicum essential oil (200 and 400 mg/kg) decreased the activity of MPO and TNF-α in the colon tissue of rats compared with the acetic acid group. Furthermore, they suppressed the expression of p-NF-κB protein induced by acetic acid administration.Conclusion: It is suggested that the anti-inflammatory effect of B. persicum essential oil on acetic acid-induced colitis in rats may be due to the suppression of NF-κB pathway. UR - https://ajp.mums.ac.ir/article_18037.html L1 - https://ajp.mums.ac.ir/article_18037_79af4ae0729968cc089f8c455462cdc3.pdf ER -