%0 Journal Article %T Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κB pathway %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Rashidian, Amir %A Akbarzadeh, Dorna %A Asgarpanah, Jinous %A Dehpour, Ahmadreza %D 2021 %\ 09/01/2021 %V 11 %N 5 %P 505-514 %! Bunium persicum essential oil reduced acetic acid-induced rat colitis through suppression of NF-κB pathway %K Bunium persicum essential oil %K Ulcerative colitis %K Acetic acid %K NF-kB %R 10.22038/ajp.2021.18037 %X Objective: The aim of this study was to evaluate the anti-inflammatory effect of B. persicum essential oil on colonic inflammation and the role of suppression of NF-κB pathway in rat colitis induced by acetic acid solution.Materials and Methods: Induction of acute colitis was done by intra-luminal instillation of 2 ml of acetic acid (4%) diluted in normal saline. Two hours after colitis induction, 0.2% tween 80 in normal saline, prednisolone (4 mg/kg) or B. persicum essential oil (100, 200, and 400 mg/kg) were administered to the rats orally and continued for 5 consecutive days. The severity of macroscopic and microscopic damages was assessed. Myeloperoxidase and TNF-α activity was evaluated by biochemical analysis and ELISA respectively and protein expression of p-NF-κB was assessed by immunohistochemistry (IHC).Results: Prednisolone and B. persicum essential oil (100, 200, and 400 mg/kg) decreased macroscopic and microscopic injuries compared to the acetic acid group. On the other hand, prednisolone and B. persicum essential oil (200 and 400 mg/kg) decreased the activity of MPO and TNF-α in the colon tissue of rats compared with the acetic acid group. Furthermore, they suppressed the expression of p-NF-κB protein induced by acetic acid administration.Conclusion: It is suggested that the anti-inflammatory effect of B. persicum essential oil on acetic acid-induced colitis in rats may be due to the suppression of NF-κB pathway. %U https://ajp.mums.ac.ir/article_18037_79af4ae0729968cc089f8c455462cdc3.pdf