Al-Aridhi D. 2014. The effect of Foeniculum
Vulgare alcoholic extract on some metabolic
changes in liver and kidneys of alloxan
diabetic mice. Iraqi J Med Sci, 12: 119-125.
Moradi Negahdari et al.
AJP, Vol. 11, No. 5, Sep-Oct 2021 492
Allemand M, Irving B, Asmann Y, Klaus K,
Tatpati L, Coddington C, Sreekumaran Nair
K. 2009. Effect of testosterone on insulin
stimulated IRS1 Ser phosphorylation in
primary rat myotubes—a potential model
for PCOS-related insulin resistance. PloS
one, 4: e4274.
Bayrami A, Shirdel A, Pouran S, Mahmoudi F,
Habibi-Yangjeh A, Singh R, Raman A.
2020. Co-regulative effects of chitosanfennel seed extract system on the hormonal
and biochemical factors involved in the
polycystic ovarian syndrome. Mater Sci
Eng, 117: 111351.
Baillargeon J, Carpentier A. 2007. Brothers of
women with polycystic ovary syndrome are
characterised by impaired glucose tolerance,
reduced insulin sensitivity and related
metabolic defects. Diabetologia, 50: 2424-
2432.
Beloosesky R, Gold R, Almog B, Sasson R,
Dantes A, Land-Bracha A, Hirsh L,
Itskovitz-Eldor J, Lessing J, Homburg R.
2004. Induction of polycystic ovary by
testosterone in immature female rats:
modulation of apoptosis and attenuation of
glucose insulin ratio. IJMCM, 14: 207-215.
Benson S, Janssen O, Hahn S, Tan S, Dietz T,
Mann K, Pleger K, Schedlowski M, Arck P,
Elsenbruch S. 2008. Obesity, depression,
and chronic low-grade inflammation in
women with polycystic ovary syndrome.
Brain Behav Immun., 22: 177-184.
Cassar S, Misso M, Hopkins W, Shaw C, Teede
H, Stepto N. 2016. Insulin resistance in
polycystic ovary syndrome: a systematic
review and meta-analysis of euglycaemic–
hyperinsulinaemic clamp studies. Hum
Reprod, 31: 2619-2631.
Connolly F, Rae M, Späth K, Boswell L,
McNeilly A, Duncan W. 2015. In an ovine
model of polycystic ovary syndrome
(PCOS) prenatal androgens suppress female
fetal renal gluconeogenesis. PLoS One, 10:
e0132113.
Di Pietro M, Parborell F, Irusta G, Pascuali N,
Bas D, Bianchi MS, Tesone M, Abramovich
D. 2015. Metformin regulates ovarian
angiogenesis and follicular development in
a female polycystic ovary syndrome rat
model. Mol Cell Endocrinol, 156: 1453-
1463.
Franks S. 1995. Polycystic ovary syndrome. N
Engl J Med, 333: 853-861.
Garimella S, Seshayamma V, Rao HJ, Kumar
S, Kumar U, Saheb S. 2016. Effect of
metformin on lipid profile of type II
diabetes. Int J Intg Med Sci, 3: 449-453.
Ghazanfarpour M, Mohammadzadeh F,
Shokrollahi P, Khadivzadeh T, Najaf Najafi
M, Hajirezaee H, Afiat M. 2018. Effect of
Foeniculum vulgare (fennel) on symptoms
of depression and anxiety in
postmenopausal women: a double-blind
randomised controlled trial. J Obstet
Gynaecol Res, 38: 121-126.
Guo X, Puttabyatappa M, Thompson RC,
Padmanabhan V. 2019. Developmental
programming: contribution of epigenetic
enzymes to antral follicular defects in the
sheep model of PCOS. Mol Cell Endocrinol,
160: 2471-2484.
Ilhan M, Ali Z, Khan IA, Tastan H, Akkol EK.
2020. Isolation and identification of
triterpenes from Anthemis austriaca Jacq.
through bioactivity-guided fractionation on
polycystic ovary syndrome rat model. Arch
Gynecol Obstet, 301: 1103-1111.
Karampoor, P, Azarnia M, Mirabolghasemi G,
Alizadeh F. 2014. The effect of
hydroalcoholic extract of fennel
(foeniculum vulgare) seed on serum levels
of sexual hormones in female wistar rats
with polycystic ovarian syndrome (PCOS).
AMUJ, 17: 70-78.
Lerchbaum E, Schwetz V, Giuliani A, Pieber
TR, Obermayer-Pietsch B. 2012. Opposing
effects of dehydroepiandrosterone sulfate
and free testosterone on metabolic
phenotype in women with polycystic ovary
syndrome. Fertil Steril, 98: 1318-1325.
Lowenstein E. 2006. Diagnosis and
management of the dermatologic
manifestations of the polycystic ovary
syndrome. Dermatol Ther, 19: 210-223.
Mahboubi M. 2019. Foeniculum vulgare as
valuable plant in management of women's
health. J Menopausal Med, 25: 1-14.
Malini N, George K. 2018. Evaluation of
different ranges of LH: FSH ratios in
polycystic ovarian syndrome (PCOS)–
Clinical based case control study. Gen
Comp Endocrinol, 260: 51-57.
Matschinsky F, Magnuson M, Zelent D, Jetton
T, Doliba N, Han Y, Taub R, Grimsby J.
2006. The network of glucokinaseexpressing cells in glucose homeostasis and
the potential of glucokinase activators for
diabetes therapy. Diabetes, 55: 1-12.
Maqbool M, Gani I, Geer M. 2019. Polycystic
Protective effects of trans-anethole and metformin on PCOS
AJP, Vol. 11, No. 5, Sep-Oct 2021 493
ovarian syndrome-a multifaceted disease: a
review. Int J Pharm Sci & Res, 10: 1072-
1079.
Nestler J, Jakubowicz D. 1997. Decreases in
ovarian cytochrome P450c17 alpha activity
and serum free testosterone after reduction
of insulin secretion in polycystic ovary
syndrome. Obstet Gynecol, 52: 112-114.
O’Reilly M, Kempegowda P, Jenkinson C,
Taylor A, Quanson J, Storbeck K, Arlt W.
2017. 11-Oxygenated C19 steroids are the
predominant androgens in polycystic ovary
syndrome. J Clin Endocrinol Metab, 102:
840-848.
Parandin R, Yousofvand N. 2019. Foeniculum
vulgare (Fennel) Effects on Puberty Timing,
Reproductive Function and Behaviour in
Adult Female Mice Following Neonatal
Exposure. J Adv Med Med Res, 27: 16-22.
Pellow J, Scott L. 2018. Medicinal plants for
primary dysmenorrhoea: A systematic
review. Complement Ther Med, 37: 13-26.
Radwan E, Zaatout H, Elghazaly M, Allam N.
2019. Interaction between ator and fennel in
the treatment of obesity in rats. J Obes
Manag, 1: 6-23.
Rather M, Dar B, Sofi S, Bhat B, Qurishi M.
2016. Foeniculum vulgare: A
comprehensive review of its traditional use,
phytochemistry, pharmacology, and safety.
Arab J Chem, 9: S1574-S83.
Rahimi R, Ardekani M. 2013. Medicinal
properties of Foeniculum vulgare Mill. in
traditional Iranian medicine and modern
phytotherapy. Chin J Integr Med, 19: 73-79.
Ramachandran V, Saravanan R. 2013. Efficacy
of asiatic acid, a pentacyclic triterpene on
attenuating the key enzymes activities of
carbohydrate metabolism in streptozotocininduced diabetic rats. Phytomedicine, 20:
230-236.
Ribstein J, Halimi J, Du Cailar G, Mimran A.
1999. Renal characteristics and effect of
angiotensin suppression in oral
contraceptive users. AJH, 33: 90-95.
Roozenburg B, Van Dessel H, Evers J, Bots R.
1997. Successful induction of ovulation in
normogonadotrophic clomiphene resistant
anovulatory women by combined
naltrexone and clomiphene citrate treatment.
J Hum Reprod, 12: 1720-1722.
Sadrefozalayi S, Farokhi F. 2014. Effect of the
aqueous extract of Foeniculum vulgare
(fennel) on the kidney in experimental
PCOS female rats. Avicenna J Phytomed, 4:
110-117.
Shams Ardekani M, Hadjiakhoondi A,
Jamshidi A, Abdi K. 2005. The study of
volatile oil of Foeniculum vulgare Miller. In
their tissue culture and comparison with the
whole plant. J Med Herb, 3: 73-80.
Sheikh B, Pari L, Rathinam A, Chandramohan
R. 2015. Trans-anethole, a terpenoid
ameliorates hyperglycemia by regulating
key enzymes of carbohydrate metabolism in
streptozotocin induced diabetic rats.
Biochim, 112: 57-65.
Singh G, Maurya S, De Lampasona M, Catalan
C. 2006. Chemical constituents, antifungal
and antioxidative potential of Foeniculum
vulgare volatile oil and its acetone extract.
Food control, 17: 745-752.
Soares Júnior J, Baracat M, Maciel G, Baracat
E. 2015. Polycystic ovary syndrome:
controversies and challenges. Rev Assoc
Med Bras, 61: 485-487.
Xia C, Liang S, He Z, Zhu X, Chen R, Chen J.
2018. Metformin, a first-line drug for type 2
diabetes mellitus, disrupts the
MALAT1/miR-142-3p sponge to decrease
invasion and migration in cervical cancer
cells. Eur J Pharmacol, 830: 59-67.
Zehra B, Khursheed A. 2018. Polycystic
ovarian syndrome: Symptoms, treatment
and diagnosis: J Pharmacogn Phytochem, 7:
875-880.
Zeng X, Xie Y, Liu Y, Long S, Mo Z. 2020.
Polycystic ovarian syndrome: correlation
between hyperandrogenism, insulin
resistance and obesity. Clin Chim Acta, 502:
214-221.
Zuo T, Zhu M, Xu W, Wang Z, Song H. Iridoids
with genipin stem nucleus inhibit
lipopolysaccharide-induced inflammation
and oxidative stress by blocking the NF-κB
pathway in polycystic ovary syndrome. Cell
Physiol Biochem, 43: 1855-1865.
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