A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety

Document Type : Review Article

Authors

1 Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

2 Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

3 Clinical Instructor Mpilo School of Midwifery Zimbabwe. Zimbabwe Confederation of Midwives, Bulawayo, Zimbabwe

Abstract

Objective: During recent years, evidence-based practice as a way to support higher standards of care was emphasized by health care policymakers. Sexual dysfunction (SD) is a common problem that affects the quality of life in individuals. Today, the use of Ginkgo biloba extract (GBE) for treating SD has been considered, so this study was performed to evaluate the current evidence for the efficacy and safety of ginkgo in treating SD.
Materials and Methods: In this review study, electronic databases of PubMed, Scopus, Cochrane, Google Scholar, Web of science and Persian databases such as SID and Magiran were searched up to March 2020, to identify all the studies reporting the effect of GBE for effectiveness on sexual function and its safety. The search was performed using the keywords of Ginkgo, Ginkgo biloba, Complementary and alternative medicine, women sexual dysfunction, and male sexual dysfunction. The quality of included studies was assessed using the Oxford Center for Evidence Based Medicine checklist.
Results: Among 156 articles found in the initial search, 5 randomized controlled trials (475 participants) were selected for this study. After a meticulous review, we found that G. biloba can have positive effects on the sexual function of postmenopausal women, while evidence shows that it has no effect on the sexual function of antidepressants users. Headaches and gastrointestinal disturbance were among the adverse events mentioned in several trials.
Conclusion: We concluded that G. biloba has limited positive effects on sexual function and more studies are needed to confirm these findings.

Keywords

References

Pebdani MA, Taavoni S, Seyedfatemi N,
Haghani H. 2014. Triple-blind, placebocontrolled trial of Ginkgo biloba extract on
sexual desire in postmenopausal women in
Tehran. Iran J Nurs Midwifery Res, 19: 262-
265.
Burkman RT. 2012. Berek & Novak’s
gynecology. JAMA, 308: 516-517.
Chen CH, Lin YC, Chiu LH, Chu YH, Ruan FF,
Liu WM, Wang PH. 2013. Female sexual
dysfunction: Definition, classification, and
debates. Taiwan J Obstet Gyne, 52: 3-7.
Cohen AJ, Bartlik B. 1998. Ginkgo biloba for
antidepressant-induced sexual dysfunction.
J Sex Marital Ther, 2: 139-43.
Culotta E, Koshland Jr DE. 1992. NO news is
good news. Science, 258: 1862-1865.
Dugoua JJ, Mills E, Perri D, Koren G. 2006.
Safety and efficacy of ginkgo (Ginkgo
biloba) during pregnancy and lactation. Can
J Clin Pharmacol, 13: 277-284.
Finkel MS, Laghrissi-Thode F, Pollock BG,
Rong J. 1996. Paroxetine is a novel nitric
oxide synthase inhibitor. Psychopharmacol
Bull, 32: 653-658.
Howick J, Chalmers I, Glasziou P, Greenhalgh
T, Heneghan C, Liberati A, Moschetti I,
Phillips B, Thornton H. 2011. The 2011
Oxford Cebm Levels of Evidence
(Introductory Document). Oxford CEBM.
Retrieved January, 20, 2011.
Higgins A, Nash M, Lynch AM. 2010.
Antidepressant-associated sexual
dysfunction: impact, effects, and treatment.
Drug healthc. patient saf, 2: 141-150.
Ito TY, Polan ML, Whipple B, Trant AS. 2006.
The enhancement of female sexual function
with ArginMax, a nutritional supplement,
among women differing in menopausal
The effect of ginkgo on sexual function
AJP, Vol. 11, No. 4, Jul-Aug 2021 331
status. J Sex Marital Ther, 32: 369-378.
Ito TY, Trant AS, Polan ML. 2001. A doubleblind placebo-controlled study of
ArginMax, a nutritional supplement for
enhancement of female sexual function. J
Sex Marital Ther, 27: 541-549.
Kang BJ, Lee SJ, Kim MD, Cho MJ. 2002. A
placebo‐controlled, double‐blind trial of
Ginkgo biloba for antidepressant‐induced
sexual dysfunction. Hum Psychopharmacol,
17: 279-284.
Lorenz T, Rullo J, Faubion S. 2016.
Antidepressant-induced female sexual
dysfunction. Mayo Clin Proc, 91: 1280-
1286.
Malakouti J, Jabbari F, Jafarabadi M,
Javadzadeh Y, Khalili A. 2017. The impact
of ginkgo biloba tablet and aromatherapy
inhaler combination on sexual function in
females during postmenopausal period: A
double-blind randomized controlled trial. Int
J Womens Health Reprod Sci, 5: 129-136.
Marcocci L, Maguire JJ, Droy-lefaix MT,
Packer L. 1994. The nitric oxide-scavenging
properties of Ginkgo biloba extract EGb
761. Biochem Biophys Res Commun, 201:
748-755.
Meston CM, Rellini AH, Telch MJ. 2008.
Short-and long-term effects of Ginkgo
biloba extract on sexual dysfunction in
women. Arch Sex Behav, 37: 530-547.
Nguyen T, Alzahrani T. 2019. Ginkgo Biloba.
StatPearls [Internet], StatPearls Publishing.
Omani-Samani R, Amini P, Navid B,
Sepidarkish M, Maroufizadeh S, AlmasiHashiani A. 2019. Prevalence of sexual
dysfunction among infertile women in Iran:
a systematic review and meta-analysis.
Fertil Steril, 12: 278-283.
Royer DL, Hickey LJ, Wing SL. 2003.
Ecological conservatism in the “living
fossil” Ginkgo. Paleobiology, 29: 84-104.
Santana LM, Perin L, Lunelli R, Inácio JFS,
Rodrigues CG, Eibel B, Goldmeier S. 2019.
Sexual dysfunction in women with
hypertension: a systematic review and metaanalysis. Curr Hypertens Rep, 21: 25-35.
Sharma J, Kalra B. 2016. Female sexual
dysfunction: Assessment. J Pak Med Assoc,
66: 623-626.
Thomas HN, Neal-Perry GS, Hess R. 2018.
Female sexual function at midlife and
beyond. Obstet Gynecol Clin, 45: 709-722.
Van-Beek TA. 2002. Chemical analysis of
Ginkgo biloba leaves and extracts. J
Chromatogr, 967: 21-55.
Van-Beek TA, Montoro P. 2009. Chemical
analysis and quality control of Ginkgo
biloba leaves, extracts, and
phytopharmaceuticals. J Chromatogr A,
1216: 2002-2032.
Wheatley D. 2004. Triple‐blind, placebo‐
controlled trial of Ginkgo biloba in sexual
dysfunction due to antidepressant d
Avicenna Journal of Phytomedicine
Volume 11, Issue 4
July and August 2021
Pages 324-331

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