TY - JOUR ID - 9880 TI - The field efficacy of Nigella sativa and Berberis vulgaris methanolic extracts against Haemoproteus columbae JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Razavi, Mostafa AU - Asadpour, Mohammad AU - Malekpour, Hossein AU - Jafari, Arash AD - Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran AD - Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Y1 - 2018 PY - 2018 VL - 8 IS - 2 SP - 114 EP - 121 KW - Nigella Sativa KW - Berberis vulgaris KW - Haemoproteus columbae KW - Pigeon DO - 10.22038/ajp.2017.18152.1707 N2 - Objective: The methanolic extracts of Nigella sativaL. seeds (MENS) and Berberis vulgaris L.(MEBV) were investigated for treatment of Haemoproteus columbae-infected pigeons (Columba livia domestica). Materials and Methods: One hundred twenty naturally-infected pigeons were randomly divided into four groups of thirty each. Two groups were treated separately with the extracts, while the positive and negative control groups were given buparvaquone (Butalex®) and distilled water, respectively. The parasitaemia rate was calculated in all groups before and after the experiment at four-day intervals for16 days. Results: The results showed a high therapeutic effect for MENS with a progressive decrease in average parasitaemia rate from 18.17% before treatment to 0.73% at the end of treatment (p<0.05), while Butalex® was able to suppress the parasitemia rate from 18.90% before treatment to 0.23% at the end of experiment (p<0.05). However, no significant changes in parasitemia rate were evident in groups treated with MEBV (p>0.05). Conclusion: Methanolic extracts of N. sativa showed therapeutic effects against H. columbae and may be regarded as a suitable choice for further studies to develop new drugs against blood parasites, in both animals and human beings. UR - https://ajp.mums.ac.ir/article_9880.html L1 - https://ajp.mums.ac.ir/article_9880_f1482e354275f9daf384d445a5d802fe.pdf ER -