TY - JOUR ID - 7073 TI - Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Kahkeshani, Niloofar AU - Gharedaghi, Milad AU - Hadjiakhoondi, Abbas AU - Sharifzadeh, Mohammad AU - Khanavi, Mahnaz AD - Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research center, Tehran University of Medical Sciences, Tehran, Iran AD - Departments of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AD - Departments of Pharmacology and Toxicology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran AD - Faculty of Land and Food Systems, University of British Columbia, B.C., Canada Y1 - 2017 PY - 2017 VL - 7 IS - 1 SP - 73 EP - 79 KW - Marrubium astracanicum KW - Pain measurment KW - Analgesic DO - 10.22038/ajp.2016.7073 N2 - Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine).  In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases. UR - https://ajp.mums.ac.ir/article_7073.html L1 - https://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdf ER -