TY - JOUR ID - 2347 TI - Evaluation of analgesic, anti-inflammatory and CNS depressant activities of methanolic extract of Lawsonia inermis barks in mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Nesa, Luthfun AU - Munira, Shirajum AU - Mollika, Shabnam AU - Islam, Md. Monirul AU - choin, Habibullah AU - Uzzaman Chouduri, Aktar AU - Naher, Nazmun AD - Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh AD - Department of Pharmacy, University of Rajshahi, Bangladesh AD - Radiant Pharmaceutical Ltd, Tongi, Bangladesh Y1 - 2014 PY - 2014 VL - 4 IS - 4 SP - 287 EP - 296 KW - Analgesic KW - Anti-inflammatory KW - Carrageenan KW - CNS depressant KW - Formalin induced pain Methanolic KW - extract of Lawsonia inermis barks KW - Writhing DO - 10.22038/ajp.2014.2347 N2 - Objectives: The study was carried out to assess the analgesic, anti-inflammatory, and CNS depressant activity of the methanolic extract of  the Lawsonia inermis barks(MELIB). Materials and Methods: Anti-inflammatory effects of MEBLI were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. Analgesic activity was measured using acetic acid-induced writhing model and formalin-induced licking and biting in mice. The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the open field and hole cross tests at a dose of 300 and 500 mg/kg body weight. Results: Statistical analysis showed that dose  of 500 mg/kg  exhibited higher analgesic activity against acetic acid-induced pain in mice than the standard drug diclofenac sodium. Furthermore, doses of 300 and 500 mg/kg caused higher percent of protection (91.16% and 95.03%, respectively) of licking and biting of formalin-induced mice than diclophenac sodium (70.72%). The Lawsonia inemis methanolic extract (300 and 500 mg/kg) alsoexhibited sustained inhibition (54.97% and 65.56%) of paw edema at the 4th hour compared with standard indomethacin (74.17%). Besides, the plant extract also had significant (p<0.05) dose-dependent CNS depressant activity. Conclusion: this study recommends that the methanolic extract of  Lawsonia inermis barks has significant analgesic, anti-inflammatory, and CNS depressant properties. UR - https://ajp.mums.ac.ir/article_2347.html L1 - https://ajp.mums.ac.ir/article_2347_a033f38b6bd2e1a3c89c725079726a43.pdf ER -