TY - JOUR ID - 2274 TI - The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hajhashemi, Valiollah AU - Dashti, Gholamreza AU - Saberi, Salabali AU - Malekjamshidi, Parvin AD - Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I. R. Iran AD - Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran Y1 - 2014 PY - 2014 VL - 4 IS - 3 SP - 144 EP - 150 KW - Essential oil KW - Heracleum persicum KW - Hyperlipidemia DO - 10.22038/ajp.2014.2274 N2 - Objective: This study was designed to investigate the effect of hydroalcoholic extract and essential oil of Heracleum persicum (Apiaceae) on lipid profile of male hyperlipidemic rabbits. Materials and Methods: Thirty rabbits were randomly divided into six groups of five each. One group received normal diet and the other groups fed with a high cholesterol (2% W/W) diet for 7 weeks. Vehicle, hydroalcoholic extract (500 and 1000 mg/kg), essential oil (200 ml/kg), and lovastatin (5 mg/kg) were administered orally to animals and their effects on lipid profile were evaluated. Results: Essential oil of H. perscum significantly (p<0.05) lowered serum triglyceride level and increased HDL-cholesterol concentration. Moreover, hydroalcoholic extract (1000 mg/kg), essential oil (200 ml/kg), and lovastatin significantly (p<0.01) reduced serum concentration of total cholesterol and LDL-cholesterol. Conclusion: These findings suggest that essential oil of the plant fruits may have some benefits in reducing cardiovascular risk factors. UR - https://ajp.mums.ac.ir/article_2274.html L1 - https://ajp.mums.ac.ir/article_2274_0f4392f00f9c758950e8c4fd44d0fa9e.pdf ER -