TY - JOUR ID - 17045 TI - The effect of royal jelly and silver nanoparticles on liver and kidney inflammation JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Pourmobini, Hossein AU - Kazemi-arababadi, Mohammad AU - Salahshoor, Mohammad Reza AU - Roshankhah, Shiva AU - Taghavi, Mohammad Mohsen AU - Taghipour, Zahra AU - Shabanizadeh, Ahmad AD - Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences AD - Department of Immunology, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran AD - Department of Anatomy, Faculty of Medicine, Social Determinants of Health Research center Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AD - Department of Anatomy, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2021 PY - 2021 VL - 11 IS - 3 SP - 218 EP - 223 KW - Kidney KW - Liver KW - Nano-silver KW - Royal jelly DO - 10.22038/ajp.2020.17045 N2 - Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver.Materials and Methods: In this project, 40 male rats were grouped as follows: 10 rats as controls, 10 rats treated with RJ; 10 rats treated with both NS and RJ and 10 rats treated with NS. Liver and kidney interleukin (IL)-1β, -2, -6, and -33 levels were determined using commercial ELISA kits.Results: RJ reduced kidney IL-6 levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-1β levels. Kidney IL-33 levels were decreased in the RJ and nano-silver groups in comparison to the NS--RJ group.Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells. UR - https://ajp.mums.ac.ir/article_17045.html L1 - https://ajp.mums.ac.ir/article_17045_f53b8a093ef7f2943c13de1dda24ab1c.pdf ER -