TY - JOUR ID - 126 TI - Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Kazemi Oskuee, Reza AU - Behravan, Javad AU - Ramezani, Mohammad AD - Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran AD - Pharmaceutical and Biotechnology Research Centers, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran Y1 - 2011 PY - 2011 VL - 1 IS - 2 SP - 83 EP - 90 KW - Carum copticum KW - Chemical composition KW - Essential oil KW - Antimicrobial activity KW - Antiviral activity DO - 10.22038/ajp.2011.126 N2 - Objectives: Evaluation of therapeutic effects of Carum copticum (C. copticum) has been the subject of several studies in recent years. Thymol the major component of C. copticum is a widely known anti-microbial agent. In this study, the antibacterial and anti viral activities of essential oil of C. copticum fruit were determined. Materials and Methods: Essential oil of C. copticum was analyzed by means of gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the oil was evaluated against six Gram (+/-) bacteria and fungi, using the micro broth dilution technique. Antiviral activity of the essential oil was evaluated using a Bacillus phage CP51. Results: From the ten identified constituents, representing 98.7% of the oil, thymol (72.3%), terpinolene (13.12%) and o-cymene (11.97%) were the major components. It was found that the oil exhibited strong antimicrobial activity againstStaphylococcus aureus (S. aureus) andBacillus subtilis (B. subtilis) (MIC, 0.00025% v/v). Furthermore, the antiviral activity of the oil was evaluated by plaque reduction assay. Conclusion: The essential oil showed an antiviral activity against phage when phage was pre-incubated with the essential oil prior to its exposure to B. cereus and without any pre-incubation with the phage, suggesting that the oil directly inactivated virus particles. UR - https://ajp.mums.ac.ir/article_126.html L1 - https://ajp.mums.ac.ir/article_126_f23f12a3bc8366fa4413bba9f8bb41f7.pdf ER -