TY - JOUR ID - 11294 TI - The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Dastani, Mostafa AU - Bigdelu, leila AU - hoseinzadeh, mahsa AU - Rahimi, Hamid Reza AU - Karimani, Asieh AU - Mohammadpour, Amir Houshang AU - Salari, Masoumeh AD - Department of cardiology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AD - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2019 PY - 2019 VL - 9 IS - 1 SP - 1 EP - 9 KW - Angina KW - Unstable KW - Arrhythmias KW - Cardiac KW - Curcumin KW - heart failure KW - Acute coronary syndrome DO - 10.22038/ajp.2018.11294 N2 - Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Materials and Methods: Forty patients with unstable angina who met the trial inclusion and exclusion criteria, participated in this double-blind randomized clinical trial. The patients were randomized into two groups: curcumin (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular arrhythmias were recorded by Holter monitors in cardiology ward, Ghaem academic hospital, Mashhad, Iran. Progression to heart failure, myocardial infarction, and pulmonary and cardiopulmonary resuscitation events as well as mortality were recorded daily throughout the study. Results: There were no significant differences between the two groups in atrial and ventricular arrhythmias (p=0.2), and other echocardiographic parameters (Ejection fraction, E, A, E/A ratio, Em, and pulmonary artery pressure) at baseline and five days after the start of the trial. Conclusion:  Nanocurcumin administered at the dose of 80 mg/day for five days had no effect in the incidence of cardiovascular complications in patients with unstable angina. UR - https://ajp.mums.ac.ir/article_11294.html L1 - https://ajp.mums.ac.ir/article_11294_dda1933a184a00daf6e141311110625f.pdf ER -