%0 Journal Article %T The field efficacy of Nigella sativa and Berberis vulgaris methanolic extracts against Haemoproteus columbae %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Razavi, Mostafa %A Asadpour, Mohammad %A Malekpour, Hossein %A Jafari, Arash %D 2018 %\ 03/01/2018 %V 8 %N 2 %P 114-121 %! The field efficacy of Nigella sativa and Berberis vulgaris methanolic extracts against Haemoproteus columbae %K Nigella Sativa %K Berberis vulgaris %K Haemoproteus columbae %K Pigeon %R 10.22038/ajp.2017.18152.1707 %X Objective: The methanolic extracts of Nigella sativaL. seeds (MENS) and Berberis vulgaris L.(MEBV) were investigated for treatment of Haemoproteus columbae-infected pigeons (Columba livia domestica). Materials and Methods: One hundred twenty naturally-infected pigeons were randomly divided into four groups of thirty each. Two groups were treated separately with the extracts, while the positive and negative control groups were given buparvaquone (Butalex®) and distilled water, respectively. The parasitaemia rate was calculated in all groups before and after the experiment at four-day intervals for16 days. Results: The results showed a high therapeutic effect for MENS with a progressive decrease in average parasitaemia rate from 18.17% before treatment to 0.73% at the end of treatment (p<0.05), while Butalex® was able to suppress the parasitemia rate from 18.90% before treatment to 0.23% at the end of experiment (p<0.05). However, no significant changes in parasitemia rate were evident in groups treated with MEBV (p>0.05). Conclusion: Methanolic extracts of N. sativa showed therapeutic effects against H. columbae and may be regarded as a suitable choice for further studies to develop new drugs against blood parasites, in both animals and human beings. %U https://ajp.mums.ac.ir/article_9880_f1482e354275f9daf384d445a5d802fe.pdf