%0 Journal Article %T Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Dougnon, Tamègnon Victorien %A Bankolé, Honoré Sourou %A Klotoé, Jean Robert %A Sènou, Maximin %A Fah, Lauris %A Koudokpon, Hornel %A Akpovi, Casimir %A Dougnon, Tossou Jacques %A Addo, Phyllis %A Loko, Frédéric %A Boko, Michel %D 2014 %\ 05/01/2014 %V 4 %N 3 %P 160-169 %! Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin %K Cholesterolemia %K Feeding %K Regulation %K Solanum macrocarpon %K Wistar rats %R 10.22038/ajp.2014.2208 %X Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 400 and 800 mg/kg of body weight. Atorvastatin was used as reference treatment drug. The data were analyzed by the Brown-Forsythe ANOVA, Dunnett’s T3 multiple comparison test, and Dunnett’s t test. All tests were done at the 5% significance level. Results: Administration of S. macrocarpon (fruits as well as leaves) resulted in a statistically significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglycerides in the treated groups compared with the untreated hypercholesterolemic group, regardless of the administrated doses. A significant increase in HDL-cholesterol was observed in the treated groups. Hepatic disorders due to the Triton have been corrected by S. macrocarpon. Conclusions: This vegetable effectively suppresses experimental hypercholesterolemia in Wistar rats, suggesting a protective role in cardiovascular diseases. Its use by individuals at risk should be promoted. %U https://ajp.mums.ac.ir/article_2208_bed2ae9de74ee7257de6220fb40f733c.pdf