%0 Journal Article %T Antidepressant-like effect of aqueous extract from Rosa damascena in mice %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Dolati, Karim %A Rakhshandeh, Hassan %A Shafei, Mohammad Naser %D 2011 %\ 09/01/2011 %V 1 %N 2 %P 91-97 %! Antidepressant-like effect of aqueous extract from Rosa damascena in mice %K Rosa damascena %K Mice %K Immobility time %K Antidepressant-like effect %R 10.22038/ajp.2011.127 %X Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST). Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injected intraperitoneally. After 30 min of injection, immobility and swimming times were measured and compared with control (negative control) and imipramine (positive control). Results: The results showed that low dose (15mg/kg) of extract significantly increased swimming time and decreased immobility time. However, the two high doses of extract (60 and 90mg/kg) had no significant effect on these parameters.  Conclusion: These results proposed antidepressant-like effect of low concentration of aqueous extract of R. damascena.   %U https://ajp.mums.ac.ir/article_127_285cfcebe1cedbd441549c3b2c89f696.pdf