@article { author = {Pourzaki, Mojtaba and Homayoun, Mansour and Sadeghi, Saeed and seghatoleslam, Masoumeh and Hosseini, Mahmoud and Ebrahimzadeh Bideskan, Alireza}, title = {Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats}, journal = {Avicenna Journal of Phytomedicine}, volume = {7}, number = {2}, pages = {116-128}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2016.7757}, abstract = {Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.Results:  All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). Administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to PTZ group.Conclusion: The results of this study allow us to conclude that C. sativum,because of its antioxidant properties, prevents from neuronal damages in PTZ rat model of seizure.}, keywords = {Coriandrum sativum,Seizure,Apoptosis,Neuronal damage,Hippocampus}, url = {https://ajp.mums.ac.ir/article_7757.html}, eprint = {https://ajp.mums.ac.ir/article_7757_06062e445614ed2f7d8ad7a3d39cf88c.pdf} }