@article { author = {Kermani, Tayyebeh and Mousavi, Seyyed Hadi and Shemshian, Maryam and Norouzy, Abdolreza and Mazidi, Mohsen and Moezzi, Atefeh and Moghiman, Toktam and Ghayour-Mobarhan, Majid and Ferns, Gordon. A.}, title = {Saffron supplements modulate serum pro-oxidant-antioxidant balance in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial}, journal = {Avicenna Journal of Phytomedicine}, volume = {5}, number = {5}, pages = {427-433}, year = {2015}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2015.4672}, abstract = {Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome. Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. The serum PAB assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention. Results: There was a significant (p=0.035) reduction in serum PAB between week 0 to week 6 and also from week 0 to week 12.  Conclusion: Saffron supplements can modulate serum PAB in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.}, keywords = {metabolic syndrome,Prooxidant-antioxidant balance,Saffron}, url = {https://ajp.mums.ac.ir/article_4672.html}, eprint = {https://ajp.mums.ac.ir/article_4672_f451efcf2aa534d165b0ab34d557ed0f.pdf} }