Effects of Musa sapientum stem extract on experimental models of anxiety

Document Type : Original Research Article

Authors

Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India

Abstract

Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice.
Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam.
Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses.
Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.

Keywords

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References

Adewoye EO, Taiwo VO, Olayioye FA. 2009. Anti-oxidant and anti-hyperglycemic activities of     musa sapientum root extracts in alloxan-induced diabetic rats. Afr J Med Med Sci, 38:109-117.
Barrett JE. 1991. Animal behavior models in the analysis and understanding of anxiolytic drugs    acting at serotonin receptors. In: Olivier B, Mos J, Slangen JL, editors. Animal models in     psychopharmacology. Switzerland: Basel Birkhauser Verlag, pp. 37–52.
Cryan JF, Sweeney FF. 2011.The age of anxiety: role of animal models of anxiolytic action in       drug discovery. Br J Pharmacol, 164:1129-1161. 
Dikshit P, Tyagi MK, Shukla K, Sharma S, Gambhir JK, Shukla R. 2011. Hepatoprotective              effect of stem of Musa sapientum Linn in rats intoxicated with carbon tetrachloride. Ann Hepatol, 10:333-339.
Emhan A, Selek S, Bayazıt H, Fatih Kİ, Katı M, Aksoy N. 2015. Evaluation of oxidative and         antioxidative parameters in generalized anxiety disorder. Psychiatry Res, 230:806-810.
Goel RK, Sairam K, Rao CV. 2001. Role of gastric antioxidant and anti-Helicobactor pylori            activities in antiulcerogenic activity of plantain banana (Musa sapientum var.   paradisiaca). Indian J Exp Biol, 39:719-722.
Grases G, Colom MA, Fernandez RA, Costa-Bauzá A, Grases F. 2014. Evidence of higher               oxidative status in depression and anxiety. Oxid Med Cell Longev, doi:         10.1155/2014/430216.
Hajhashemi V, Rabbani M, Ghanadi A, Davari E. 2010. Evaluation of antianxiety and sedative   effects of essential oil of Ducrosia anethifolia in mice. Clinics, 65:1037-1042.
Kessler RC. 2007. The global burden of anxiety and mood disorders: putting the European Study of the Epidemiology of Mental Disorders (ESEMeD) findings into perspective. J Clin              Psychiatry,68:10-19.
 Krolow R, Arcego DM, Noschang C, Weis SN, Dalmaz C. 2014. Oxidative imbalance and               anxiety disorders. Curr Neuropharmacol, 12:193-204.
Kumar GP, Khanum F. 2012. Neuroprotective potential of phytochemicals. Pharmacogn Rev,       6:81-90.
Michel Bourin. 2015. Animal models for screening anxiolytic-like drugs: a perspective.     Dialogues Clin Neurosci, 17:295-303.
Pellow S, File S. 1986. Anxiolytic and anxiogenic drug effects on exploratory activity in an              elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav, 24:525-       529
Pereira A, Maraschin M. 2015. Banana (Musa spp) from peel to pulp: ethnopharmacology,            source of bioactive compounds and its relevance for human health. J Ethnopharmacol,    160:149-163. 
Reddy AJ, Handu SS, Dubey AK, Mediratta PK, Shukla R, Ahmed QM. 2016.  Effect of Musa       sapientum Stem Extract on Animal Models of Depression. Pharmacogn Res,                 8:249-252.
Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L,   Lydiard RB, Massie MJ, Katon W, Laden SK, Stein MB. 2008. Anxiety disorders and    comorbid               medical illness. Gen Hosp Psychiatry, 30:208-225.
Sajja VS, Hubbard WB, VandeVord PJ. 2015. Subacute Oxidative Stress and Glial Reactivity in    the Amygdala are Associated with Increased Anxiety Following Blast Neurotrauma. Shock, Suppl 1:71-78.
Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M.              2015. Oxidative stress as an etiological factor and a potential treatment target of                psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism. Pharmacol      Rep, 67:569-580.
Tsai MC, Huang TL. 2016. Increased activities of both superoxide dismutase and catalase were    indicators of acute depressive episodes in patients with major depressive disorder.               Psychiatry Res, 235:38-42.
Turner R. 1965. Screening Methods in Pharmacology. Vol. 1. New York: Academic Press, p. 26.
Trebaticka J, Durackova Z. 2015. Psychiatric Disorders and Polyphenols: Can They Be    Helpful in Therapy? Oxid Med Cell Longev, doi:10.1155/2015/248529
 
Avicenna Journal of Phytomedicine
Volume 7, Issue 6
November and December 2017
Pages 495-501

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