Effect of Phaleria macrocarpa on sexual function of rats

Document Type : Original Research Article

Authors

1 Medicinal Plants Research Centre, Yasuj University of Medical Sciences (YUMS), Yasuj, Iran

2 Biomedical Department, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia

Abstract

Objectives: The purpose of current study was to determine the effect of Phaleria macrocarpa (P. macrocarpa)fruits aqueous extract on reproductive performance of adult male rats by assessing the serum testosterone level and evaluating their libido behavior.
Methods and Materials: Eighteen male adult Spraque Dawley rats were divided into three groups and designated as treatment (240 mg/kg P. macrocarpaaqueous extract), negative control (distilled water), and positive control (4 mg/kg testosterone) which were supplemented through intragastric gavage for seven weeks. On the seventh week of supplementation, each of the male rats was introduced to five female rats at five different days to allow mating and observed the libido behavior. The mounting latency and mounting frequency were recorded for each mating.
Results: P. macrocarpa aqueous extract significantly increased (p<0.05) the serum testosterone level and mounting frequency of male rats. However, there was no significant effect on mounting latency.  Body weight was significantly lower in rats supplemented with P. macrocarpa aqueous extract compared with the control groups (p<0.05).
Conclusion: P. macrocarpa showed potential value as an alternative for improving the sexual strength by increasing the level of testosterone and libido behavior. Thus, it is suggested that P. macrocarpa can improve the fertility in man.
 

Keywords

References

Ajeng D, Subarnas A, Supriyatna S, Levita J, Abdulah R. 2012. Cytotoxicity of fevicordin-A from Phaleria macrocarpa (Scheff.) Boerl on P 388, HeLa, CasKi, TE-2, TE-8 and Prepuce’s Fibroblast cells. J Med Res,1: 1-5.

Ali RB, Atangwho IJ, Kuar N, Mariam Ahmad M, Roziahanim Mahmud R, Mohd Z Asmawi MZ. 2013. In vitro and in vivo effects of standardized extract and fractions of Phaleria macrocarpa fruits pericarp on lead carbohydrate digesting enzymes. BMC Complement Altern Med, 13: 39. 

Al-Sa'aidi JAA, Al-Khuzai ALD, Al-Zobaydi NFH. 2009. Effect of alcoholic extract of Nigella sativa on fertility in male rats. Iraqi J Vet Sci, 23, Suppl.II: 123-128.
Backer C, van den Brink R. 1965. Flora of Java (Spermatophytes Only), vol. II. Groningen, Netherlands, Noordhoff.
Chong SC, Dollah MA, Chong PP, Maha A. 2011. Phaleria macrocarpa (Scheff.) Boerl fruit aqueous extract enhances LDL receptor and PCSK9 expression in vivo and in vitro. J  Ethnopharmcol,137: 817-827.
Concept Fertility Centre. 2006. Available at: http://www.conceptfertility.com.my. Accessed on: 10 January 2012.
Gauthaman K, Adaikan PG, Prasda RNV. 2002. Aphrodisiac properties of Tribulus terrestis extract (protodioscin) in normal and castrated rats. Life Sci,71:1385-1396.
Gray JM, Nunez AA, Siegel LI, Wade GN. 1979. Effects of testosterone on body weight and adipose tissue: Role of aromatization. J Physiol Behav, 23: 465-469.
Harvey J, Berry JA. 2009. Andropause in the Aging Male. J Nurse Pract, 5: 207-212.
Hendra R, Ahmad S, Sukari A, Shukor MY, Oskoueian E. 2011. Flavonoid Analyses and Antimicrobial Activity of Various Parts of Phaleria macrocarpa (Scheff.) Boerl Fruit. Int J Mol Sci, 12: 3422-3431.
Izzati NI. 2010. Toxicity effect of Phaleria macrocarpa on kidney functions in rats. Unpublished Thesis, University Putra Malaysia, Malaysia.
Rhoden EL, Morgentaler A. 2004. Risks of Testosterone-Replacement Therapy and Recommendations for Monitoring. New Engl J Med, 350:482-492.
Shane-McWhorter L. 2001.  Biological complementarytherapies: a focus on botanical products in diabetes.Diabetes Spectr, 14: 199-208.
Willingham J. 2007. Why men can have hot flashes too. Available at: http://www.physicalfitnessarticles.net/Article/Why-Men-Can-Have-Hot-Flashes-Too/18952. Accessed on: 12 February 2012
Yakubu MT, Akanji MA, Oladiji AT. 2005. Aphrodisiac potentials of aqueous extract of Fadogia agrestis (Schweinf. Ex Heirn) stem in male albino rats. Asian J Androl, 7: 399-404.
Yang NJ, Kaphle K, Wang P, Jang D, Wa L, Lin J. 2004. Effect of aqueous extracts of “Betel Quid” and its constituents on testosterone production by dispersed mouse intestinal cell. Am J Chinese Med, 32: 705-715.
Yeh GY, Eisenberg DM, Kaptcuk TJ, Philips RS. 2003. System review of herbs and dietary supplements for glycemic control in diabetes.  Diabetes Care, 2003, 26: 1277-1294.
Zhang Y, Xu X, Liu H. 2006. Chemical constituents from Mahkota dewa.J Asian Nat Prod Res,8: 119-123.
 
 
 
Avicenna Journal of Phytomedicine
Volume 3, Issue 4 - Serial Number 4
September and October 2013
Pages 371-377

Files

Share

How to cite

Statistics