The adjuvant therapy of edible herbal product including colchicum bulb, olive leaf, black cumin seeds, lavender flower, and ginger rhizome on the outcome of patients with severe and critical COVID-19: A double-blind randomized controlled clinical trial

Sebghatollahi, Vahid; Siavash Dastjerdi, Mansour; Ghiasi, Farzin; Alikiaii, Babak; Pourahmad, Morteza; Yegdaneh, Afsaneh; Akbari, Mojtaba; Ghadiri, Reza

doi:10.22038/ajp.2024.24633

The adjuvant therapy of edible herbal product including colchicum bulb, olive leaf, black cumin seeds, lavender flower, and ginger rhizome on the outcome of patients with severe and critical COVID-19: A double-blind randomized controlled clinical trial

Document Type : Original Research Article

Authors

¹ Department of Gastroenterology and Hepatology, Isfahan University of Medical Sciences, Isfahan, Iran

² Department of Endocrine and Metabolism, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

³ Department of Pulmonary Diseases, Isfahan University of Medical Sciences, Isfahan, Iran

⁴ Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

⁵ Department of Infectious Disease and Tropical Medicine, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

⁶ Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

⁷ Department of Epidemiology, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

⁸ Department of Traditional Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

10.22038/ajp.2024.24633

Abstract

Objective: The present study aimed at evaluating the effect of combination of medicinal plants, including Colchicum autumnal L., Olea europaea L., Nigella sativa L., Lavandula angustifolia L., and Zingiber officinale Roscoe, on the recovery and outcome of COVID-19 patients.
Materials and Methods: This study was conducted on 150 COVID-19 patients. All patients received both pharmaceutical and supportive treatments. In addition to the standard care treatment, intervention group received two capsules of herbal medicine orally every 8 hours, while control group received placebo.
Results: Oxygen saturation percentage (SpO2) of the intervention group (median:88.00) was significantly higher than that of the control group (median:86.00), while C-reactive protein (CRP) of the intervention group (median:20.00) was significantly lower than that of the control group (median:28.00) at the time of hospital discharge (p<0.05).
Conclusion: The combination of studied medicinal plants could significantly reduce the oxygen requirement and oxygen therapy.

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