Effect of Bunium persicum aqueous extract plus endurance exercise on cardiorespiratory capacity and serum lipid profile

Document Type : Original Research Article

Authors

1 Physiology Research Center and Department of Physiology, Kerman University of Medical Sciences, Kerman, I. R. Iran

2 Department of Physical Education, Shahid Bahonar University, Kerman, I. R. Iran

3 Physiology Research Center and Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Objective(s): We examined the effects of endurance exercise in the presence of Bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice.
Materials and Methods: Forty male hypercholesterolemic mice were divided into four groups: Vehicle, Endurance exercise (EE), Bunium persicum extract (BPE), and EE + BPE. The exercise protocol was performed at a speed of 18 m/min, 40 min/day, and 5 days/week for 6 weeks. The BPE was administered orally by a dose of 20 mg/Kg/day.
Results: The results indicated that the 6-week endurance training accompanied by Bunium Persicum extract administration increased cardiorespiratory capacity significantly (601±39 vs. 293±20 meters, p<0.001). Total cholesterol level was significantly reduced in EE + BPE compared with Vehicle and EE groups (p<0.05). LDL-c was lower in EE + BPE compared with the Vehicle (p<0.01). HDL-c in BPE and EE + BPE groups was significantly higher than Vehicle (pConclusion: The results suggested that Bunium persicum extract is very useful in improvement of lipid profile in hypercholesterolemic animals. Supplementation of the extractto exercise significantly increased the cardiorespiratory capacity.

Keywords

Main Subjects

References

Al-Jarrah M, Pothakos K, Novikova L, Smirnova IV, Kurz MJ, Stehno-Bittel L, Lau YS. 2007. Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration. Neuroscience, 149: 28-37.
LemhadriL, HajjiJ, MichelB, Eddouks M.  2006. Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol, 106: 321-326.
Al Hassan S, Reese KA, Mahurin J, Plaisance EP, Hilson BD, Garner JC, Wee SO, Grandjean PW. 2006. Blood lipid responses to plant stanol ester supplementation and aerobic exercise training. Metabolism, 55: 541-549.
Asgary S, Sarrafzadegan N, Naderi GA, Rozbehani R. 2008. Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter? Lipids Health Dis, 7: 42-48.
Azizi F , Rahmani  M , Emami H , Mirmiran  P, et al. 2002.Tehran lipid and glucose study, Methodology and summarized findings, 1st Ed., Tehran Endocrine and Metabolism Research Center, 40- 65, Tehran, ran.
Asha Devi S, Prathima S, Subramanyam MV 2003. Dietary vitamin E and physical exercise: In: A. Lemhadri, L. Hajji, J.-B. Michel,, M. Eddouks.  2006. Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol, 106: 321-326.
 Chandra M, Rajkumar M, Debidas G. 2006. Comparative Study on Antihyperglycemic and Antihyperlipidemic Effects of Separate and Composite Extract of Seed of Eugenia jambolana and Root of Musa paradisiaca in Streptozotocin-Induced Diabetic Male Albino Rat. Ir J Pharmacol Therapeut, 5, 1:27-33
Dadkhah A, Fatemi F. 2011. Heart and kidney oxidative stress status in septic rats treated with caraway   extracts,  49: 679-686.
Dhandapani S, Subramanian VR, Rajagopal S, Namasivayam N. 2002. Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. Pharmacol  Res, 46: 251-255.
Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. 2001. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med, 31: 1033-1062.
Durstine JL, Haskell W L. 1994. Effects of exercise training on plasma lipids and lipoproteins. Exerc Sport Sci Rev, 22: 477-521.
Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC. 1998. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA, 280:1569-1575.
  Ensign WY.,  McNamara DJ.,  Fernandez ML. 2002. Exercise improves plasma lipid profiles and modifies lipoprotein composition in guinea pigs. J Nutr Biochem, 13: 747-753.
Fallah-Hosseini H, Fakhr-zadeh H. 2006. Review of anti-hyperlipidemic herbal medicine. J Med Plants, 5: 9-20.
Gaeini AA, Rajabi H. 2005. Physical fitness. Samt publication, Tehran, Iran: pp. 36-8 (Book in Persian)
Haidari F, Seyed-Sadjadi N, Taha-Jalali M, Mohammed-Shahi M.  2011. The effect of oral administration of Carum carvi on weight, serum glucose, and lipid profile in streptozotocin-induced diabetic rats. Saudi Med J, 32: 695-700
Hoerger TJ, Bala MV, Bray JW, Wilcosky TC,  LaRosa J. 1998. Treatment patterns and distribution of low-density lipoprotein cholesterol levels in treatment-eligible United States adults. Am J Cardiol, 82: 61-65
Kessler RC, Davis RB, Foster DF, Van Rompay MI, Walters EE, Wilkey SA, Kaptchuk TJ, Eisenberg DM. 2001. Long-term trends in the use of complementary and alternative medical therapies in the United States. Ann Intern Med, 135: 262-268.
Khabazian BM, Ghanbari-Niaki A, Safarzadeh-Golpordesari A, Ebrahimi M, R, Abednazari H. 2009. Endurance training enhances ABCA1 expression in rat small intestine.ahbarizadeh F.  Eur J Appl Physiol, 107: 351-358.
Khanna K, Rizvi F, Chander R. 2002. Lipid lowering activity of Phylanthus niruri in hyperlipidemic rats.  J Ethnopharmacol,82: 19-22.
Kist WB, Thomas TR, Horner KE, Laughlin MH. 1999. Effects of Aerobic training and gender on HDL-c and LDL-c subfractions in yucatan miniature swine J Exerc Physiol Online, 2: 7-15.
Luo QF, Sun L Si JY, Chen DH 2008. Hypocholesterolemic effect of stilbenes containing extract-fraction    from Cajanus cajan L. on diet-induced hypercholesterolemia in mice. Phytomedicine. 11: 932-939
Moathar F, Shams-Ardakani MR. 2000. Guide in plant therapy. Academic Publication of Medical Sciences, p.39, Tehran, Iran (Book in Persian).
Rajlakshmi D, Sharma DK. 2004. Hypolipidemic effect of different extracts of clerodendron colebrookranum in normal and high-fat diet fed rats. J Ethnopharmacol, 90: 63-68
Ravi Kiran T, Subramanyam MVV, Prathima S, Asha Devi S. 2006. Blood lipid profile and myocardial superoxide dismutase in swim-trained young and middle-aged rats: comparison between left and right ventricular adaptations to oxidative stress. J Comp Physiol, 176: 749-762.
Roberts S, Robergs R. 2000. Fundamental principles of exercise physiology for fitness, Performance and Health:
Essentials of Strength Training and Conditioning - 3rd Edition, McGraw-Hill.
Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie   P, Steinberger J, Thom T, Wilson M,  Hong Y .2008. Heart disease and stroke statistics- 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 117: e25-146.
Rimmer JH, Looney MA. 1997. Effects of an aerobic activity program on the cholesterol levels of adolescents. Res Q Exerc Sport, 68: 74-79.
Stein RA, Michielli DW, Glantz, MD, Sardy H. 2002. Effects of different exercise training intensities on lipoproteins cholesterol fractions in health middle aged men.  Am Heart J, 119: 277-283.
Sharma SB, Nasir A, Prabhu KM. Murthy PS, Dev G. 2003. Hypoglycemic and hypolipidemic effect of ethanol extract of seeds of Eugenia Jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol, 85: 201-206.
van Oort G, Gross DR, Spiekerman AM.  1987. Effects of eight weeks of physical conditioning on atherosclerotic plaque in swine. Am J Vet Res, 48: 51-55.
Venditti P, Dimeo SD. 1996. Antioxidant. Tissue damages and endurance in trained and untrained young male rats. Arch. Biochem Biophys, 331: 63-66.
Volaklis KA, Spassis AT, Tokmakidis SP 2007. Land versus water exercise in patients with coronary artery disease: effects on body composition, blood lipids, and physical fitness. Am Heart J, 154: e561-566.
Von Duvillard SP, Foxall TL, Davis WP, Terpstra AH. 2000. Effects of exercise on plasma high-density lipoprotein cholesteryl ester metabolism in male and female miniature swine. Metabolism, 49: 826-832

Avicenna Journal of Phytomedicine
Volume 4, Issue 2 - Serial Number 2
March and April 2014
Pages 118-126

Files

Share

How to cite

Statistics