Almora-Pinedo Y, Arroyo-Acevedo J,
Herrera-Calderon O, Chumpitaz-Cerrate V,
Hañari-Quispe R, Tinco-Jayo A, FrancoQuino C, Figueroa-Salvador L. 2017.
Preventive effect of Oenothera rosea on Nmethyl-N-nitrosourea-(NMU) induced
gastric cancer in rats. Clin Exp
Gastroenterol, 10: 327-332.
Andrade-Cetto A. 2009. Ethnobotanical study
of the medicinal plants from Tlanchinol,
Hidalgo, Mexico. J Ethnopharmacol, 122:
163-171.
Argueta VA, Cano AML, Rodarte ME. 1994.
Atlas de las plantas de la medicina
tradicional mexicana. Instituto Nacional
Indigenista, 2: 765-766.
Bannon AW, Malmberg AB. 2007. Models of
nociception: hot-plate, tail-flick, and
formalin tests in rodents. Curr Protoc
Neurosci, Chapter 8: Unit 8.9.
Barnes PJ. 2006. Corticosteroids: the drugs to
beat. Eur J Pharmacol, 533: 2-14.
Carullo G, Cappello AR, Frattaruolo L,
Badolato M, Armentano B, Aiello F. 2017.
Quercetin and derivatives: useful tools in
inflammation and pain management. Future
Med Chem, 9: 79-93.
Vargas-Ruiz et al.
AJP, Vol. 12, No. 4, Jul-Aug 2022 412
Coşkun Ö, Kanter M, Armutçu F, Çetin K,
Kaybolmaz B, Yazgan Ö. 2004. Protective
effects of quercetin, a flavonoid
antioxidant, in absolute ethanol-induced
acut gastric ulcer. Eur J Gen Med, 1: 37-42.
Cury Y, Picolo G, Gutierrez VP, Ferreira SH.
2011. Pain and analgesia: The dual effect of
nitric oxide in the nociceptive system.
Nitric oxide, 25: 243-254.
D’Amour FE, Smith DL. 1941. A method for
determining loss of pain sensation. J
Pharmacol Exp Ther, 72: 74-79.
Díaz Porras HV, Fuertes Ruitón C, Whu Whu
D, Jurado Teixeira B, Roque Alcarraz M,
Arroyo Acevedo J. 2011. Antiplatelet effect
in vivo and fibrinolytic in vitro ethanol
extract leaves Oenothera rosea Aiton
(chupasangre). Rev Soc Quím Perú, 77:
225-234.
Dunham NW, Miya TS. 1957. A Note on a
simple apparatus for detecting neurological
deficit in rats and mice. J Am Pharm
Assoc, 46: 208-209.
Ferreira SH, Duarte I, Lorenzetti BB. 1991.
The molecular mechanism of action of
peripheral morphine analgesia: stimulation
of the cGMP system via nitric oxide
release. Eur J Pharmacol, 201: 121-122.
Filho AW, Filho VC, Olinger L, de Souza
MM. 2008. Quercetin: further investigation
of its antinociceptive properties and
mechanisms of action. Arch Pharm Res, 31:
713-721.
Francis SH, Busch JL, Corbin JD, Sibley D.
2010. cGMP-dependent protein kinases and
cGMP phosphodiesterases in nitric oxide
and cGMP action. Pharmacol Rev, 62: 525-
563.
Frias B, Merighi A. 2016. Capsaicin,
nociception and pain. Molecules, 21: 797.
Guardia T, Rotelli AE, Juarez AO, Pelzer LE.
2001. Anti-inflammatory properties of
plant flavonoids. Effects of rutin, quercetin
and hesperidin on adjuvant arthritis in rat. Il
farmaco, 56: 683-687.
Hatt KM, Vijapura A, Maitin IB, Cruz E.
2018. Safety considerations in prescription
of NSAIDs for musculoskeletal pain: A
narrative review. PM&R, 10: 1404-1411.
Hiruma-Lima CA, Gracioso JS, Toma W,
Almeida AB, Paula AC, Brasil DS, Muller
AH, Souza Brito AR. 2001.
Gastroprotective effect of aparisthman, a
diterpene isolated from Aparisthmium
cordatum, on experimental gastric ulcer
models in rats and mice. Phytomedicine, 8:
94-100.
Hole K, Tjølsen A. 2007. Tail flick test.
Encyclopedia of pain. Berlin: Springer:
2392-2395.
Hooman Khademi M, Farin Kamangar M,
Paul Brennan M, Reza Malekzadeh M.
2016. Opioid therapy and its side effects: a
review. Arch Iran Med, 19: 870.
Hunskaar S, Hole K. 1987. The formalin test
in mice: dissociation between inflammatory
and non-inflammatory pain. Pain, 30: 103-
114.
Janicki PK, Jeske-Janicka M. 1998. Relevance
of nitric oxide in pain mechanisms and pain
management. Curr Rev Pain, 2: 211-216.
Levy L. 1969. Carrageenan paw edema in the
mouse. Life Sci 8: 601-606.
Liang J, Dou Y, Wu X, Li H, Wu J, Huang Q,
Luo D, Yi T, Liu Y, Su Z, Chen J. 2018.
Protective effect of patchoulene epoxide
against ethanol-induced gastric ulcer in
rats: Influence on oxidative stress,
inflammation and apoptosis. Chem Biol
Interact, 283: 30-37.
Mann A, Chesselet MF. 2015. Chapter 8 -
Techniques for Motor Assessment in
Rodents A2 - LeDoux, Mark S. Movement
Disorders (Second Edition). pp. 139-157.
Boston, Academic Press.
Márquez-Flores Y, Meléndez-Camargo M,
García-Mateos N, Huerta-Anaya M, PabloPérez S, Silva-Torres R. 2018.
Phytochemical composition and
pharmacological evaluation of different
extracts of Oenothera rosea L´ Hér. ex Ait
(Onagraceae) aerial part. S Afr J Bot, 116:
245-250.
Márquez-Flores YK, Montellano-Rosales H,
Campos Alderete ME, Meléndez-Camargo
ME. 2009. Anti-inflammatory activity of
aqueous and methanolic extracts of
Oenothera rosea L'Hér. ex Ait in the rat.
Rev Mex Cienc Farm, 40: 11-16.
Meckes M, David-Rivera AD, Nava-Aguilar
V, Jimenez A. 2004. Activity of some
Mexican medicinal plant extracts on
carrageenan-induced rat paw edema.
Phytomedicine, 11: 446-451.
Medzhitov R. 2008. Origin and physiological
roles of inflammation. Nature, 454: 428-
435.
Newman DJ, Cragg GM. 2020. Natural
products as sources of new drugs over the
nearly four decades from 01/1981 to
Antinociceptive and anti-inflammatory effect of O. rosea
AJP, Vol. 12, No. 4, Jul-Aug 2022 413
09/2019. J Nat Prod, 83: 770-803.
Noriega V, Miranda HF, Prieto JC,
Sotomayor-Zárate R, Sierralta F. 2020.
Involvement of NO in antinociception of
NSAIDS in murine formalin hind paw
assay. Drug res, 70: 145-150.
Park HH, Lee S, Son HY, Park SB, Kim MS,
Choi EJ, Singh TS, Ha JH, Lee MG, Kim J
E. 2008. Flavonoids inhibit histamine
release and expression of proinflammatory
cytokines in mast cells. Arch Pharm Res,
31: 1303.
Pinho-Ribeiro FA, Hohmann MS, Borghi SM,
Zarpelon AC, Guazelli CF, Manchope MF,
Casagrande R, Verri WA. 2015. Protective
effects of the flavonoid hesperidin methyl
chalcone in inflammation and pain in mice:
Role of TRPV1, oxidative stress, cytokines
and NF-κB. Chem Biol Interact, 228: 88-
99.
Raja SN, Carr DB, Cohen M, Finnerup NB,
Flor H, Gibson S, Keefe FJ, Mogil JS,
Ringkamp M, Sluka KA, Song XJ, Stevens
B, Sullivan MD, Tutelman PR, Ushida T,
Vader K. 2020. The revised international
association for the study of pain definition
of pain: concepts, challenges, and
compromises. Pain, 161: 1976-1982.
Ren K, Dubner R. 2010. Interactions between
the immune and nervous systems in pain.
Nat Med, 16: 1267-1276.
Reyes-Garcia G, Deciga-Campos M, MedinaSantillan R, Granados-Soto V. 2007.
Comparison of antinociceptive efficacy and
gastroprotection between celecoxib and
diclofenac plus misoprostol in rats. Proc
West Pharmacol Soc, 50: 69-71.
Rossato MF, Trevisan G, Walker CIB, Klafke
JZ, de Oliveira AP, Villarinho JG, Zanon
RB, Royes LFF, Athayde ML, Gomez MV.
2011. Eriodictyol: a flavonoid antagonist of
the TRPV1 receptor with antioxidant
activity. Biochem Pharmacol, 81: 544-551.
Rzasa Lynn R, Galinkin J. 2018. Naloxone
dosage for opioid reversal: current evidence
and clinical implications. Ther Adv Drug
Saf, 9: 63-88.
Rzedowski J. 2005. Flora fanerogámica del
Valle de México. Instituto de Ecología.
Sachs D, Cunha FQ, Ferreira SH. 2004.
Peripheral analgesic blockade of
hypernociception: activation of
arginine/NO/cGMP/protein kinase G/ATPsensitive K+ channel pathway. Proc Natl
Acad Sci USA, 101: 3680-3685.
Sakurada T, Katsumata K, Tan-No K,
Sakurada S, Kisara K. 1992. The capsaicin
test in mice for evaluating tachykinin
antagonists in the spinal cord.
Neuropharmacology, 31: 1279-1285.
Schug SA, Palmer GM, Scott DA, Halliwell
R, Trinca J. 2016. Acute pain management:
scientific evidence, fourth edition, 2015.
Med J Aust, 204: 315-317.
Shah S, Mehta V. 2012. Controversies and
advances in non-steroidal antiinflammatory drug (NSAID) analgesia in
chronic pain management. Postgrad Med J,
88: 73-78.
Singh S, Kaur R, Sharma SK. 2012. An
updated review on the Oenothera genus.
Zhong Xi Yi Jie He Xue Bao, 10: 717-725.
Tjolsen A, Berge OG, Hunskaar S, Rosland J
H, Hole K. 1992. The formalin test: an
evaluation of the method. Pain, 51: 5-17.
Vargas-Ruiz R, Montiel-Ruiz RM, HerreraRuiz M, Gonzalez-Cortazar M, BleGonzalez EA, Jimenez-Aparicio AR,
Jimenez-Ferrer E, Zamilpa A. 2020. Effect
of phenolic compounds from Oenothera
rosea on the kaolin-carrageenan induced
arthritis model in mice. J Ethnopharmacol,
253: 112711.
Xu Y, Xu M Y, Li X. 2008. Modulation of
gamma-aminobutyric acid on painful sense
in central nervous system of morphinedependent rats. Neurosci Bull, 24: 278-282.
Zeilhofer HU, Möhler H, Di Lio A. 2009.
GABAergic analgesia: new insights from
mutant mice and subtype-selective
agonists. Trends Pharmacol Sci, 30: 397-
402.
Zhang JM, An J. 2007. Cytokines,
inflammation and pain. Int Anesthesiol
Clin, 45: 27-37.
Zimmermann M. 1983. Ethical guidelines for
investigations of experimental pain in
conscious animals. Pain, 16: 109-110