Abdollahi M, Karimpour H, Monsef-Esfehani
HR. 2003. Antinociceptive effects of
Teucrium polium L. total extract and
essential oil in mouse writhing test.
Pharmacol Res, 48: 31-35.
Ahmadian-Attari MM, Ahmadiani A,
Kamalinejad M, Dargahi L, Shirzad M,
Mosaddegh M. 2015. Treatment of
Alzheimer’s disease in Iranian traditional
medicine. Iran Red Crescent Med, 17: 1-7.
Al-Asmari AK, Al-Elaiwi AM, Athar MT,
Tariq M, Al Eid A, Al-Asmary SM. 2014.
A review of hepatoprotective plants used
in Saudi traditional medicine. Evid Based
Complement Alternat Med, 2014.
Ali SK, Hamed AR, Soltan MM, Hegazy UM,
Elgorashi, EE, El-Garf IA, Hussein AA.
2013. In-vitro evaluation of selected
Egyptian traditional herbal medicines for
the treatment of Alzheimer disease. BMC
Complement Altern Med, 13: 121-130.
Ali-Shtayeh MS, Jamous RM, Jamous RM.
2016. Traditional Arabic Palestinian
ethnoveterinary practices in animal health
care: a field survey in the West Bank
(Palestine). J Ethnopharmacol, 182: 35-49.
Alizadeh AM, Sohanaki H, Khaniki M,
Mohaghgheghi MA, Ghmami G, Mosavi
M. 2011. The effect of Teucrium Polium
Hney on the wound healing and tensile
strength in rat. Iran J Basic Med. Sci, 14:
499-505.
Al-Qahdi SS, Alzohari N, Alsaid AY, Ashour
AA, Aboulkassim T, Vranic S, Khalil AA.
2019. Teucrium polium plant extract
provokes substantial cytotoxicity at the
early stage of embryonic development.
Bosn J Basic Med Sci, 19: 67-71.
Amiri MS, Joharchi MR. 2013. Ethnobotanical
investigation of traditional medicinal
plants commercialized in the markets of
Mashhad, Iran. Avicenna J Phytomed, 3:
254-271.
Asadi Y, Farahmandfar R. 2020. Frying
stability of canola oil supplemented with
ultrasound‑assisted extraction of Teucrium
polium. Nutr Food Sci, 8: 1187-1196.
Amraee S, Bahramikia S, Mohammadi AS.
2020. The effective fraction of Teucrium
polium suppressed polyol pathway through
inhibiting the aldose reductase enzyme: a
strategy to reduce retinopathy. J Med
Plants Res, 19: 82-90.
Baali N, Belloum Z, Baali S, Chabi B,
Pessemesse L, Fouret G, Cabello G. 2016.
Protective activity of total polyphenols
from Genista quadriflora Munby and
Teucrium polium geyrii Maire in
acetaminophen-induced hepatotoxicity in
rats. Nutrients, 8: 193-232.
Bahmani M, Saki K, Shahsavari S, RafieianKopaei M, Sepahvand R, Adineh A. 2015.
Identification of medicinal plants effective
in infectious diseases in Urmia, northwest
of Iran. Asian Pac J Trop Biomed, 5: 858-
864.
Bahramikia S, Yazdanparast R. 2012.
Phytochemistry and medicinal properties
of Teucrium polium L. (Lamiaceae).
Phytother Res, 26: 1581-1593.
Baluchnejadmojarad T, Roghani M, RoghaniDehkordi F. 2005. Antinociceptive effect
of Teucrium polium leaf extract in the
diabetic rat formalin test. J
Ethnopharmacol, 97: 207-210.
Bezić N, Vuko E, Dunkić V, Ruščić M,
Blažević I, Burčul F. 2011. Antiphytoviral
activity of sesquiterpene-rich essential oils
Biological activities of Teucrium polium
AJP, Vol. 12, No. 3, May-Jun 2022 237
from four Croatian Teucrium species.
Molecules, 16: 8119-8129.
Boghrati Z, Naseri M, Rezaie M, Pham N,
Quinn RJ, Tayarani-Najaran Z, Iranshahi
M. 2016. Tyrosinase inhibitory properties
of phenylpropanoid glycosides and
flavonoids from Teucrium polium L. var.
gnaphalodes. Iran J Basic Med Sci, 19:
804-811.
Capasso F, De Fusco R, Fasulo MP, Lembo
M, Mascolo N, Menghini A. 1984.
Antipyretic and antibacterial actions of
Teucrium polium (L.). Pharmacol Res
Commun, 16: 21-29.
Dağ M, Özturk Z, Aydınlı M, Koruk İ,
Kadayıfçı A. 2014. Postpartum
hepatotoxicity due to herbal medicine.
Teucrium polium. Ann Saudi Med, 34:
541-543.
De Marino S, Festa C, Zollo F, Incollingo F,
Raimo G, Evangelista G, Iorizzi, M. 2012.
Antioxidant activity of phenolic and
phenylethanoid glycosides from Teucrium
polium L. Food Chem, 133: 21-28.
Djabou N, Lorenzi V, Guinoiseau E, Andreani
S, Giuliani MC, Desjobert JM, Muselli A.
2013. Phytochemical composition of
Corsican Teucrium essential oils and
antibacterial activity against foodborne or
toxi-infectious pathogens. Food Control,
30: 354-363.
Ebadollahi A, Taghinezhad E. 2019. Modeling
and optimization of the insecticidal effects
of Teucrium polium L. essential oil against
red flour beetle (Tribolium castaneum
Herbst) using response surface
methodology. Inf Process Agric, 7: 286-
293.
Eissa TAF, Palomino OM, Carretero ME,
Gómez-Serranillos MP. 2014.
Ethnopharmacological study of medicinal
plants used in the treatment of CNS
disorders in Sinai Peninsula, Egypt. J
Ethnopharmacol, 151: 317-332.
El Atki Y, Aouam I, El Kamari F, Taroq A,
Lyoussi B, Oumokhtar B, Abdellaoui A.
2020. Phytochemistry, antioxidant and
antibacterial activities of two Moroccan
Teucrium polium L. subspecies:
Preventive approach against nosocomial
infections. Arab J Chem, 13: 3866-3874.
El Atki Y, Aouam I, Taroq A, Lyoussi B,
Taleb M, Abdellaoui A. 2019. Total
phenolic and flavonoid contents and
antioxidant activities of extracts from
Teucrium polium growing wild in
Morocco. Mater Today Proc, 13: 777-783.
El Oualidi J, Verneau O, Puech S, Dubuisson
JY. 1999. Utility of rDNA ITS sequences
in the systematics of Teucrium
sectionPolium (Lamiaceae). Plant Syst
Evol, 215: 49-70.
Elmasri WA, Hegazy MEF, Aziz M, Koksal E,
Amor W, Mechref Y, Paré PW. 2014.
Biofilm blocking sesquiterpenes from
Teucrium polium. Phytochemistry, 103:
107-113.
Essid R, Rahali FZ, Msaada K, Sghair I,
Hammami M, Bouratbine A, Limam F.
2015. Antileishmanial and cytotoxic
potential of essential oils from medicinal
plants in Northern Tunisia. Ind Crops
Prod,77:795-802.
Feinbrun-Dothan N. 1978. Flora Palaestina,
Part three. ISAH, 101-106.
Fiorentino AD, Abrosca B, Pacifico S,
Scognamiglio MD, Angelo G, Gallicchio
M Monaco P. 2011. Structure elucidation
and hepatotoxicity evaluation against
HepG2 human cells of neo-clerodane
diterpenes from Teucrium polium L.
Phytochemistry, 72:2037-2044.
Fitsiou E, Pappa A. 2019. Anticancer Activity
of Essential Oils and Other Extracts from
Aromatic Plants Grown in Greece.
Antioxidants, 8:290-307.
Forouzandeh H, Azemi ME, Rashidi I,
Goudarzi M, Kalantari H. 2013. Study of
the protective effect of Teucrium polium
L. extract on acetaminophen-induced
hepatotoxicity in mice. Iran J Pharm Res,
12:123-129.
Gharaibeh MN, Elayan HH, Salhab AS. 1988.
Hypoglycemic effects of Teucrium polium.
J Ethnopharmacol, 24:93-99.
Goulas V, Gomez-Caravaca AM, Exarchou V,
Gerothanassis IP, Segura-Carretero A,
Gutiérrez AF. 2012. Exploring the
antioxidant potential of Teucrium polium
extracts by HPLC–SPE–NMR and on-line
radical-scavenging activity detection.
LWT, 46:104-109.
Hasanein P, Shahidi S. 2012. Preventive effect
of Teucrium polium on learning and
memory deficits in diabetic rats. Med Sci
Mon Int Med J Exp Clin Res, 18:BR41-
BR46.
Hayta S, Polat R, Selvi S. 2014. Traditional
uses of medicinal plants in Elazığ
(Turkey). J Ethnopharmacol, 154:613-623.
Bahramikia et al.
AJP, Vol. 12, No. 3, May-Jun 2022 238
Hemmati Hassan Gavyar P, Amiri H. 2018.
Chemical composition of essential oil and
antioxidant activity of leaves and stems of
Phlomis lurestanica. Int J Food Prop,
21:1414-1422.
Hosseinkhani A, Falahatzadeh M, Raoofi E,
Zarshenas MM. 2017. An evidence-based
review on wound healing herbal remedies
from reports of traditional Persian
medicine. Evid Based Complement
Alternat Med, 22:334-343.
Hussain J, Rehman NU, Al-Harrasi A, Ali L,
Khan AL, Albroumi MA. 2013. Essential
oil composition and nutrient analysis of
selected medicinal plants in Sultanate of
Oman. Asian Pac J Trop Dis, 3:421-428.
Jadeja R, Devkar RV, Nammi S. 2014. Herbal
medicines for the treatment of
nonalcoholic steatohepatitis: current
scenario and future prospects. Evid Based
Complement Alternat Med, 2014.
Kasabri V, Afifi FU, Hamdan I. 2011. In vitro
and in vivo acute antihyperglycemic
effects of five selected indigenous plants
from Jordan used in traditional medicine. J
Ethnopharmacol, 133:888-896.
Khadige K, Keshavarz Z, Mojab F, Majd HA,
Abbasi NM. 2016. Comparison the effect
of mefenamic acid and Teucrium polium
on the severity and systemic symptoms of
dysmenorrhea. Complement Ther Clin
Pract, 22:12-15.
Khaled-Khodja N, Boulekbache-Makhlouf L,
Madani K. 2014. Phytochemical screening
of antioxidant and antibacterial activities
of methanolic extracts of some Lamiaceae.
Ind Crops Prod, 61:41-48.
Khani A, Heydarian M. 2014. Fumigant and
repellent properties of sesquiterpene-rich
essential oil from Teucrium polium subsp.
capitatum (L.). Asian Pac J Trop Dis,
7:956-961.
Khoshnood-Mansoorkhani MJ, Moein MR,
Oveisi N. 2010. Anticonvulsant activity of
Teucrium polium against seizure induced
by PTZ and MES in mice. Iran J Pharm
Res, 9:395-401.
Krishnaiah D, Sarbatly R, Nithyanandam R.
2011. A review of the antioxidant potential
of medicinal plant species. Food Bio prod
Process, 89: 217-233.
Kristanc L, Kreft S. 2016. European medicinal
and edible plants associated with subacute
and chronic toxicity part I: Plants with
carcinogenic, teratogenic and endocrinedisrupting effects. Food Chem Toxicol,
92: 150-164.
Lin NH, Yang HW, Su YJ, Chang CW. 2019.
Herb induced liver injury after using
herbal medicine: A systemic review and
case-control study. Medicine, 98: e14992.
Lobbens ES, Vissing KJ, Jorgensen L, van de
Weert M, Jäger AK. 2017. Screening of
plants used in the European traditional
medicine to treat memory disorders for
acetylcholinesterase inhibitory activity and
anti amyloidogenic activity. J
Ethnopharmacol, 200: 66-73.
Mahmoudabady M, Haghshenas M, Niazmand
S. 2018. Extract from Teucrium polium L.
protects rat heart against oxidative stress
induced by ischemic–reperfusion injury.
Adv Biomed Res, 7: 15.
Mahmoudabady M, Shafei MN, Niazmand S,
Khodaee E. 2014. The effects of
hydroalcoholic extract of Teucrium polium
L. on hypertension induced by angiotensin
II in rats. Int J Prev Med, 5: 1255-1260.
Masoudi S. 2018. Volatile constituents from
different parts of three Lamiacea herbs
from Iran. Iran J Pharm Res, 17: 365-376.
Meguellati H, Ouafi S, Saad S, Djemouai N.
2019. Evaluation of acute, subacute oral
toxicity and wound healing activity of
mother plant and callus of Teucrium
polium L. subsp. geyrii Maire from
Algeria. S Afr J Bot, 127: 25-34.
Miara MD, Bendif H, Rebbas K, Rabah B,
Hammou MA, Maggi F. 2019. Medicinal
plants and their traditional uses in the
highland region of Bordj Bou Arreridj
(Northeast Algeria). J Herb Med, 16:
100262.
Miikaili P, Shayegh J, Asghari MH. 2012.
Review on the indigenous use and
ethnopharmacology of hot and cold
natures of phytomedicines in the Iranian
traditional medicine. Asian Pac J Trop
Biomed, 2: S1189-S1193.
Mousavi SE, Shahriari A, Ahangarpour A,
Vatanpour H, Jolodar A. 2012. Effects of
Teucrium polium ethyl acetate extract on
serum, liver and muscle triglyceride
content of sucrose-induced insulin
resistance in rat. Iran J Pharm Res, 11:
347-355.
Mousavi SM, Niazmand S, Hosseini M,
Hassanzadeh Z, Sadeghnia HR, Vafaee F,
Keshavarzi Z. 2015. Beneficial effects of
Teucrium polium and metformin on
Biological activities of Teucrium polium
AJP, Vol. 12, No. 3, May-Jun 2022 239
diabetes-induced memory impairments
and brain tissue oxidative damage in rats.
Int J Alzheimers Dis, 2015: 1-8.
Movahedi A, Basir R, Rahmat A, Charaffedine
M, Othman F. 2014. Remarkable
anticancer activity of Teucrium polium on
hepatocellular carcinogenic rats. J Evid
Based Complementary Altern Med, 2014:
1-9.
Naghibi F, Mosadegh M, Mohammadi MS,
Ghorbani AB. 2005. Labiatae family in
folk medicine in Iran: from ethnobotany to
pharmacology. Iran J Pharm Res, 2: 63-79.
Nasab FK, Khosravi AR. 2014. Ethnobotanical
study of medicinal plants of Sirjan in
Kerman Province. J Ethnopharmacol, 154:
190-197.
Niazmand S, Esparham M, Hassannia T,
Derakhshan M. 2011. Cardiovascular
effects of Teucrium polium L. extract in
rabbit. Pharmacogn Mag, 7: 260-264.
Niazmand S, Fereidouni E, Mahmoudabady
M, Hosseini M. 2017. Teucrium poliuminduced vasorelaxation mediated by
endothelium-dependent and endotheliumindependent mechanisms in isolated rat
thoracic aorta. Pharmacogn J, 9: 372-377.
Nor M, Huda N, Othman F, Tohit M, Rahayu
E, Md Noor S, Hassan H. 2019. In Vitro
Antiatherothrombotic effects of extracts
from Berberis Vulgaris L., Teucrium
Polium L., and Orthosiphon Stamineus
Benth. Evid Based Complement Alternat
Med, 2019: 1-10.
Othman MB, Salah-Fatnassi KBH, Ncibi S,
Elaissi A, Zourgui, L. 2017. Antimicrobial
activity of essential oil and aqueous and
ethanol extracts of Teucrium polium L.
subsp. gabesianum (LH) from Tunisia.
Physiol Mol Biol Plants, 23: 723-729.
Ouelbani R, Bensari S, Mouas TN, Khelifi, D.
2016. Ethnobotanical investigations on
plants used in folk medicine in the regions
of Constantine and Mila (North-East of
Algeria). J Ethnopharmacol, 194: 196-218.
Polat R, Satıl F. 2012. An ethnobotanical
survey of medicinal plants in Edremit Gulf
(Balıkesir–Turkey). J Ethnopharmacol,
139: 626-641.
Pour MG, Mirazi N, Seif A. 2019. Treatment
of liver and spleen illnesses by herbs:
Recommendations of Avicenna’s heritage"
Canon of Medicine". Avicenna J
Phytomed, 9: 101-116.
Rafieian-Kopaei M, Nasri H, Baradaran, A.
2014. Teucrium polium: Liver and kidney
effects. J Res Med Sci, 19: 478-479.
Rahmouni F, Hamdaoui L, Badraoui R, Rebai
T. 2017. Protective effects of Teucrium
polium aqueous extract and ascorbic acid
on hematological and some biochemical
parameters against carbon tetrachloride
(CCl4) induced toxicity in rats. Biomed
Pharmacother, 91: 43-48.
Raja RR. 2012. Medicinally potential plants of
Labiatae (Lamiaceae) family: an overview.
Res J Med Plant, 6: 203-213.
Ravan S, Khani A, Sufi S. 2019. Fumigant
toxicity and sublethal effects of Teucrium
polium essential oil on Aphis fabae scopoli
A. Chin Herb Med, 11: 231-235.
Sadeghi Z, Kuhestani K, Abdollahi V,
Mahmood A. 2014. Ethnopharmacological
studies of indigenous medicinal plants of
Saravan region, Baluchistan, Iran. J
Ethnopharmacol, 153: 111-118.
Safaeian L, Ghanadian M, Shafiee-Moghadam
Z. 2018. Antihyperlipidemic effect of
different fractions obtained from Teucrium
polium hydroalcoholic extract in rats. Int J
Prev Med, 9: 30.
Salehi B, Venditti A, Sharifi-Rad M, Kręgiel
D, Sharifi-Rad J, Durazzo A, Antolak H.
2019. The therapeutic potential of
apigenin. Int J Mol Sci, 20: 1305.
Salimnejad R, Sazegar G, Borujeni MJS,
Mousavi SM, Salehi F, Ghorbani F. 2017.
Protective effect of hydroalcoholic extract
of Teucrium polium on diabetes-induced
testicular damage and serum testosterone
concentration. Int J Reprod Biomed
(Yazd), 15: 195-202.
Sayyad R, Farahmandfar R. 2017. Influence of
Teucrium polium L. essential oil on the
oxidative stability of canola oil during
storage. Int J Food Sci Technol, 54: 3073-
3081.
Sheikhbahaei F, Khazaei M, NematollahiMahani SN. 2018. Teucrium polium
extract enhances the anti-angiogenesis
effect of tranilast on human umbilical vein
endothelial cells. Adv Pharm Bull, 8: 131-
139.
Simonyan KV, Chavushyan VA. 2016.
Protective effects of hydroponic Teucrium
polium on hippocampal neurodegeneration
in ovariectomized rats. BMC Complement
Altern Med, 16: 1-8.
Stankovic MS, Curcic MG, Zizic JB,
Topuzovic MD, Solujic SR, Markovic SD.
Bahramikia et al.
AJP, Vol. 12, No. 3, May-Jun 2022 240
2011. Teucrium plant species as natural
sources of novel anticancer compounds
antiproliferative, proapoptotic and
antioxidant properties. Int J Mol Sci, 12:
4190-4205.
Suleiman MS, Abdul-Ghani AS, Al-Khalil S,
Amin R. 1988. Effect of Teucrium polium
boiled leaf extract on intestinal motility
and blood pressure. J Ethnopharmacol, 22:
111-116.
Tabatabaie PS, Yazdanparast R. 2017.
Teucrium polium extract reverses
symptoms of streptozotocin-induced
diabetes in rats via rebalancing the Pdx1
and FoxO1 expressions. Biomed
Pharmacother, 93: 1033-1039.
Tariq M, Ageel AM, Al-Yahya MA, Mossa
JS, Al-Said MS. 1989. Anti-inflammatory
activity of Teucrium poliumis. Int J Tissue
React, 11: 185-188.
Tatar M, Qujeq D, Feizi F, Parsian H, Faraji
AS, Halalkhor S, Mir H. 2012. Effects of
Teucrium Polium aerial parts extract on
oral glucose tolerance tests and pancreas
histopathology in Streptozocin-induced
diabetic rats. Int J Mol Cell Med, 1: 44-49.
Uritu CM, Mihai CT, Stanciu GD, Dodi G,
Alexa-Stratulat T, Luca A, Tamba BI.
2018. Medicinal plants of the family
Lamiaceae in pain therapy: A review. Pain
Res Manag, 2018: 7801543.
Vahdani M, Faridi P, Zarshenas MM,
Javadpour S, Abolhassanzadeh Z, Moradi
N, Ghasemi Y. 2011. Major compounds
and antimicrobial activity of essential oils
from five Iranian endemic medicinal
plants. Pharmacogn Mag, 3: 48-53.
Venditti A. 2017. Secondary metabolites from
Teucrium polium L. collected in Southern
Iran. AJMAP, 3: 108-123.
Venditti A, Frezza C, Trancanella E, Zadeh
SMM, Foddai S, Sciubba F, Bianco A.
2017. A new natural neo-clerodane from
Teucrium polium L. collected in Northern
Iran. Ind Crops Prod, 97: 632-638.
Vilas-Boas V, Gijbels E, Jonckheer J, De
Waele E, Vinken M. 2020. Cholestatic
liver injury induced by food additives,
dietary supplements and parenteral
nutrition. Environ Int, 136: 1-11.
Vladimir-Knežević S, Blažeković B, Kindl M,
Vladić J, Lower-Nedza AD, Brantner AH.
2014. Acetylcholinesterase inhibitory,
antioxidant and phytochemical properties
of selected medicinal plants of the
Lamiaceae family. Molecules, 19: 767-
782.
Williams P, Sorribas A, Howes MJR. 2011.
Natural products as a source of
Alzheimer's drug leads. Nat Prod Rep, 28:
48-77.
)